Boswellic acids are bioactive compounds derived from the resin of the Boswellia serrata tree, commonly known as Indian frankincense, and are primarily used in traditional Ayurvedic medicine for their anti-inflammatory properties. These pentacyclic triterpenes, particularly acetyl-11-keto-β-boswellic acid (AKBA), inhibit pro-inflammatory enzymes like 5-lipoxygenase, making them a popular natural supplement for managing chronic inflammatory conditions [1].

Health Benefits

Anti-inflammatory Effects for Osteoarthritis: Boswellic acids have shown promise in reducing pain and improving mobility in patients with osteoarthritis by inhibiting inflammatory mediators. A randomized controlled trial demonstrated that 333 mg of Boswellia serrata extract three times daily for 8 weeks significantly reduced knee pain and improved function compared to placebo [2].
Asthma Management: These compounds may help alleviate asthma symptoms by reducing leukotriene synthesis, which contributes to airway inflammation. A clinical study found that 300 mg of Boswellia extract three times daily for 6 weeks improved lung function and reduced asthma attacks in participants [3].
Support for Inflammatory Bowel Disease (IBD): Boswellic acids exhibit potential in managing IBD, such as ulcerative colitis, through anti-inflammatory and antioxidant mechanisms. Research indicates that 350 mg of Boswellia extract three times daily for 6 weeks led to remission in a significant number of patients with ulcerative colitis, comparable to standard mesalazine therapy [4].

Boswellic acids have moderate bioavailability, which can be enhanced when taken with fatty meals due to their lipophilic nature; however, they may interact with medications like anticoagulants or antiplatelet drugs, potentially increasing bleeding risk [1].

Dosage and Safety

Dosage recommendations typically range from 300-500 mg of standardized Boswellia extract (containing 30-60% boswellic acids) taken 2-3 times daily, with a common regimen of 333 mg three times per day for inflammatory conditions.
Safety considerations include mild side effects such as nausea, diarrhea, or acid reflux; they are generally well-tolerated but contraindicated in pregnancy, breastfeeding, or with bleeding disorders, and long-term use should be monitored by a healthcare provider.

Conclusion

In summary, boswellic acids offer evidence-based benefits for inflammation-related conditions like osteoarthritis, asthma, and IBD, making them a valuable natural supplement when used appropriately under medical supervision to maximize efficacy and minimize risks.

NUMEVO Catalogue des éléments nutritifs

Filtrer les nutriments

Vitamines & Vitaminoïdes

Minéraux

Lipides et acides gras

Acides aminés et dérivés

Prébiotiques et probiotiques

Enzymes

Précurseurs hormonaux

Peptides

Substances botaniques et naturelles

Polysaccharide

Produits pharmaceutiques