Fisetin is a naturally occurring flavonoid polyphenol found in various fruits and vegetables, such as strawberries, apples, persimmons, onions, and cucumbers. It is primarily used as a dietary supplement for its potential anti-aging, antioxidant, and anti-inflammatory properties, with ongoing research exploring its role in promoting cellular health and longevity [1].

Health Benefits

Anti-Aging and Senolytic Effects: Fisetin acts as a senolytic agent, selectively eliminating senescent cells that contribute to aging and age-related diseases. A study published in Nature Medicine demonstrated that fisetin extended lifespan and reduced senescence markers in mice, suggesting potential benefits for human aging processes [2].
Neuroprotective Benefits: Fisetin may protect against cognitive decline and neurodegenerative diseases like Alzheimer's by reducing inflammation and oxidative stress in the brain. Research in the journal Frontiers in Aging Neuroscience showed that fisetin improved memory and reduced neuroinflammation in animal models of Alzheimer's disease [3].
Anti-Inflammatory and Antioxidant Properties: Fisetin exhibits strong anti-inflammatory effects by inhibiting pro-inflammatory pathways and scavenging free radicals. A review in Pharmacological Research highlighted its ability to modulate NF-κB signaling, potentially benefiting conditions like arthritis and cardiovascular disease [4].

Fisetin's bioavailability is relatively low due to poor water solubility, but it can be enhanced when taken with fats or in liposomal formulations. It may interact with certain medications, such as blood thinners, so caution is advised [1].

Dosage and Safety

Dosage recommendations typically range from 100–200 mg per day for general health benefits, based on human pilot studies and extrapolation from animal research; higher doses (e.g., 1,000–1,500 mg intermittently) have been used in senolytic protocols but require medical supervision [5].
Safety considerations include generally mild side effects like digestive upset in high doses, with limited long-term human data available; it is contraindicated in pregnant or breastfeeding individuals and those on anticoagulants due to potential interactions [1].

Conclusion

In summary, fisetin offers promising benefits for anti-aging, brain health, and inflammation reduction, supported by preclinical evidence, making it a valuable supplement for those seeking to support cellular vitality. Always consult a healthcare provider before use, especially given the emerging nature of human research.

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