Best nutrients for Longevity

Evidence-ranked nutrients and supplements that may support Longevity. Explore each for benefits, dosage, safety and the underlying research.

35 nutrients

10/10Coenzyme Q10 (Ubiquinol)The mitochondrial energy catalyst and potent antioxidant for heart health, fertility, and cellular vitality
9/10Astragalus ExtractThe ancient immune tonic and cellular defender
7/10RapamycinRapamycin (sirolimus) is an mTOR inhibitor used for immunosuppression and studied for longevity and cancer prevention effects.
6/10Calcium Alpha-KetoglutarateThe Krebs cycle metabolite that declines with age and may support cellular energy, muscle health, and biological aging pathways.
5/10Extra Virgin Olive OilExtra Virgin Olive Oil (EVOO) is a nutrient-rich, cold-pressed oil valued for its cardiovascular, anti-inflammatory, and antioxidant benefits, most notably as part of a Mediterranean diet.
5/10Oligomeric Proanthocyanidins (OPC)Oligomeric Proanthocyanidins (OPCs) are plant polyphenols with potent antioxidant, vascular, and skin-protective benefits.
3/10SpermidineSpermidine is a natural polyamine shown to support cellular health, longevity, and cardiovascular and brain function, mainly by promoting autophagy.
3/10Hyaluronic AcidHyaluronic acid is a naturally occurring molecule used as an oral supplement to support joint health, skin hydration, and tissue repair.
3/10DHEADHEA is a steroid hormone supplement primarily used for hormone regulation, mood support, and bone health, particularly in older adults or those with adrenal insufficiency.
3/10Reishi ExtractReishi extract (Ganoderma lucidum) is a medicinal mushroom supplement valued for immune modulation, stress support, and antioxidant benefits.
3/10Sophora JaponicaSophora japonica is a flavonoid-rich plant traditionally used for vascular and antioxidant support.
3/10Broccoli Sprout ExtractBroccoli sprout extract is a supplement rich in sulforaphane, supporting antioxidant defenses, detoxification, and cellular health.
3/10PolyphenolsPolyphenols are plant-derived compounds with antioxidant and anti-inflammatory effects, commonly found in fruits, vegetables, tea, and wine.
3/10Japanese Knotweed ExtractJapanese Knotweed Extract is a plant-derived supplement rich in resveratrol and polydatin, known for antioxidant and anti-inflammatory effects.
3/10Grape Seed ExtractAntioxidant-rich supplement derived from grape seeds, primarily used for cardiovascular, antioxidant, and skin health benefits.
3/10Grape Vine Leaf ExtractExtract of Vitis vinifera leaves, used for chronic venous insufficiency and vascular support due to its antioxidant and anti-inflammatory properties.
3/10Coenzym Q10 (Ubiquinone)Coenzyme Q10 (CoQ10, ubiquinone) is a fat-soluble antioxidant involved in cellular energy production and supports heart, muscle, and brain health.
3/10Green Tea PolyphenolsGreen tea polyphenols are potent plant antioxidants primarily found in green tea leaves, supporting cardiometabolic health and weight management.
3/10ShilajitShilajit is a natural mineral-rich resin used in Ayurvedic medicine, supported by emerging evidence for benefits in cognition, testosterone, bone health, and antioxidant capacity.
3/10L-GlutathioneL-Glutathione is a major cellular antioxidant tripeptide that supports detoxification, immune health, and cellular defense against oxidative stress.
3/10QuercetinQuercetin is a plant-based antioxidant flavonoid that may support cardiovascular, immune, and inflammatory health.
3/10DiosgeninDiosgenin is a plant-derived steroidal sapogenin with anti-inflammatory, metabolic, and potential hormone-modulating effects.
3/10Trans-ResveratrolTrans-Resveratrol is a polyphenolic antioxidant found in grapes and berries, researched for its cardiovascular, anti-inflammatory, and neuroprotective effects.
3/10Rosemary leafRosemary leaf is an herb traditionally used for memory, digestion, and as an antioxidant, with emerging evidence supporting cognitive and anti-inflammatory benefits.
2/10ApigeninApigenin is a natural plant flavonoid studied for its antioxidant, anti-inflammatory, calming, and anticancer properties.
2/10NMN (Nicotinamide Mononucleotide)NMN is a precursor to NAD+ that shows early promise for metabolic, cognitive, and aging-related benefits, but robust human evidence is limited.
2/10FisetinNaturally occurring flavonoid with senolytic, antioxidant, and anti-inflammatory potential, under study for longevity and brain health.
2/10Nicotinamide RibosideNicotinamide riboside (NR) is a vitamin B3 derivative that acts as a precursor to NAD+, supporting cellular energy, metabolism, and healthy aging.
2/10KetosteroneKetosterone (7-Keto DHEA) is a non-hormonal DHEA metabolite used to support metabolism and weight management.
2/10Decaffeinated Green Tea ExtractDecaffeinated green tea extract is a concentrated source of tea polyphenols without caffeine, used for antioxidant support and overall wellness.
2/10Agaricus blazeiAgaricus blazei is a medicinal mushroom with potential immune-modulating and anti-inflammatory properties, commonly used in traditional and integrative medicine.
2/10Shitake ExtractShiitake extract is derived from Lentinula edodes mushrooms and is used for immune support, cholesterol management, and potential adjunctive cancer therapy.
2/10FlavonoidsFlavonoids are plant-derived polyphenols with antioxidant and anti-inflammatory properties that may support heart health, immune function, and longevity.
2/10Alpha-Ketoglutaric AcidAlpha-ketoglutaric acid (AKG) is an intermediate of the Krebs cycle, commonly used as a supplement for energy support, exercise, longevity, and organ health.
1/10EpithalonEpithalon is a synthetic peptide studied for potential anti-aging and longevity effects but is not approved for human use outside research settings.

Last updated: April 12, 2026