Malate
Malate (malic acid) is a Krebs cycle intermediate used to support energy production, alleviate fibromyalgia symptoms, and address dry mouth, most often in combination with magnesium.
Malate, the ionized form of malic acid, is found naturally in various fruits and serves as a key intermediate in cellular energy metabolism. It is commonly used as a supplement, often paired with magnesium, for its potential benefits in fatigue reduction, fibromyalgia, and oral health.
Most evidence for malate’s supplement benefits involves its combination with magnesium, especially in fibromyalgia; benefits for fatigue and oral health are based on a small number of clinical trials and mechanistic rationale.
May reduce fibromyalgia symptoms, especially pain and tenderness
LimitedSupplementation with malate, particularly combined with magnesium, may decrease pain and tender points in people with fibromyalgia.
May help improve fatigue and support cellular energy
LimitedAs a Krebs cycle intermediate, malate may enhance cellular energy production and reduce fatigue, as shown in animal models and limited human studies.
May relieve symptoms of dry mouth (xerostomia)
LimitedMalate-containing oral sprays can increase salivary flow and comfort in people with dry mouth, especially medication-induced xerostomia.
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