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Cissus Quadrangularis
Extract

Moderate study situation·7/10
A higher score indicates better study conditions, but not necessarily effectiveness.

Traditional herbal extract shown to support bone healing, joint comfort, and metabolic health, with emerging evidence in humans.

dose range
300–600 mg
1–2 doses daily, often with food.
Consumption
Take with meals to reduce the risk of gastrointestinal upset and improve absorption.
Not fat-soluble.
Best time
Best split into morning and/or first meal; follow standardized extract recommendations (e.g., 2.5% ketosteroids) where possible.
Description

Cissus quadrangularis is a plant widely used in Ayurveda for bone and joint health. Modern extracts concentrate ketosteroids and flavonoids, and are increasingly studied for benefits in fracture healing, joint pain, and weight management.

benefits
Main effects with level of evidence
Moderate
Note on evidence

Most evidence comes from animal studies and small to medium clinical trials; larger and longer-term RCTs are still limited.

Supports bone healing and regeneration

Moderate

Supplementation with Cissus quadrangularis extract may accelerate fracture healing and improve bone mineralization, based on animal studies and limited human data.

Particularly relevant for: adults with fractures · individuals at risk of osteoporosis

Reduces joint pain and inflammation

Moderate

May help decrease joint pain, stiffness, and inflammation, with clinical studies showing improvements in osteoarthritis and sports injuries.

Particularly relevant for: athletes · older adults with joint discomfort

Aids weight management and metabolic health

Limited

Cissus quadrangularis extract may support weight loss and modestly improve metabolic markers, possibly through effects on appetite, adiponectin, and lipid metabolism.

Particularly relevant for: overweight adults · individuals seeking metabolic support

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This information is for educational purposes only and does not replace medical advice.

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This website is for educational and informational purposes only and does not constitute medical advice or professional services. The information provided should not be used to diagnose or treat any health problem or disease. Persons requiring medical advice should consult a licensed physician.