What is Dimethyl Glycine (DMG)?

Dimethyl Glycine (DMG), also called dimethylglycine, is a glycine derivative produced in small amounts in the body and found in some foods. It is sold as a dietary supplement.

What are the potential benefits of DMG?

DMG is marketed for energy, immune function, and exercise performance. Human clinical evidence is limited, and benefits are not consistently confirmed.

What is a typical DMG dosage?

Common supplemental amounts are about 100–500 mg per day. Follow product directions and consider discussing dosing with a clinician, especially if you have medical conditions.

Is DMG safe and what are possible side effects?

DMG is generally well tolerated for many people at typical supplement doses, but side effects can occur. Stop use and seek medical advice if you develop concerning symptoms or reactions.

Does DMG help with cognitive function or autism?

DMG has been studied as an adjunct in conditions such as autism spectrum disorder, but controlled evidence has not established clear cognitive benefits. It should not replace standard care.

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Dimethyl Glycine
(DMG)

Limited research available·3/10

A higher score indicates better study conditions, but not necessarily effectiveness.

Dimethylglycine (DMG) is a naturally occurring compound marketed as a dietary supplement for energy, immune function, and exercise performance, with limited human clinical evidence.

Cognitive Enhancement Exercise Performance Immune Booster Liver Health Energy Support

dose range

100–500 mg

1–2 divided doses per day

Consumption

DMG can be taken with or without food.

Not fat-soluble.

Best time

No strict timing required; take with or without meals.

Description

Dimethylglycine (DMG) is a derivative of the amino acid glycine, produced in small amounts in the human body and found in certain foods. It is promoted to support energy, immunity, cognitive function, and athletic performance, though robust clinical evidence is limited.

benefits

Main effects with level of evidence

Limited

Note on evidence

While DMG is widely marketed for several health benefits, available research in humans is scarce, with most effects observed in preliminary, small-scale, or animal studies.

Supports immune response (limited evidence)

Limited

Preliminary studies suggest that DMG supplementation may support aspects of immune function by enhancing antibody responses, particularly under physical stress, but robust evidence in humans is lacking.

Particularly relevant for: athletes · individuals seeking immune support

examine_dmg · Examine.com: Dimethylglycine (DMG)pmid_15330136 · Efficiency of dimethylglycine in increasing oxygen utilization and immune response

May improve exercise performance (limited evidence)

Limited

Some animal studies and a few small human trials suggest DMG could aid oxygen utilization during exercise, though consistent, clinically meaningful benefits in athletes have not been confirmed.

Particularly relevant for: athletes · active individuals

examine_dmg · Examine.com: Dimethylglycine (DMG)pmid_15330136 · Efficiency of dimethylglycine in increasing oxygen utilization and immune response

Potential support for cognitive function (theoretical)

Theoretical

DMG was previously investigated as an adjunct in conditions such as autism spectrum disorder, but quality controlled studies have not established cognitive benefits.

Particularly relevant for: individuals seeking cognitive enhancement

cochrane_autismspectrum · Cochrane Review: DMG in autism spectrum disorders examine_dmg · Examine.com: Dimethylglycine (DMG)

Potential role in mitochondrial and liver health (theoretical)

Theoretical

DMG is involved in methylation and mitochondrial activity, and it is used for liver health in some contexts, but clinical trials are lacking.

Particularly relevant for: individuals with mitochondrial disorders · those interested in liver support

lpi_dmg · Linus Pauling Institute: DMG Research pmid_16566782 · Dimethylglycine in mitochondrial diseases: review

Safety & Information

Important safety information & known risks

For educational purposes only • not medical advice

DMG supplementation is generally well-tolerated at typical doses, but safety has not been thoroughly established, especially in higher risk groups.

warning notices

Use only under medical supervision if you have a seizure disorder or take psychiatric medications.
Safety has not been established in pregnant or breastfeeding women.
Adverse effects are rare but may include irritability or overstimulation.
Avoid DMG supplements if you have unmanaged epilepsy unless used under clinical supervision.
Use caution and consult a healthcare provider if pregnant, breastfeeding, or taking medications for psychiatric or seizure disorders.

Known interactions with medications

Possible interaction with antiepileptic drugs.

Contraindications / special precautions

History of epilepsy or seizure disorder without clinician oversight.

interactions

Important interactions between active ingredient ↔ supplement / medication / food

DMG has limited known supplement or drug interactions, but may theoretically affect medications relevant to seizure disorders and methylation pathways.

Use caution with antiepileptic drugs

drug · Antiepileptic drugs

CautionLimited

Why

DMG has been reported anecdotally and in case reports to potentially lower seizure threshold in some individuals.

recommendation

Consult a healthcare provider if taking antiepileptics or with seizure history before using DMG.

examine_dmg · Examine.com: Dimethylglycine (DMG)ods_dmg · NIH Office of Dietary Supplements: Dimethylglycine

mechanisms of action

Brief explanations of how it works

Methyl donor in one-carbon metabolism

DMG acts as a methyl group donor, influencing homocysteine metabolism and supporting methylation pathways involved in DNA and neurotransmitter synthesis.

lpi_dmg · Linus Pauling Institute: DMG Research examine_dmg · Examine.com: Dimethylglycine (DMG)