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Rapamycin

Moderate study situation·7/10
A higher score indicates better study conditions, but not necessarily effectiveness.

Rapamycin (sirolimus) is an mTOR inhibitor used for immunosuppression and studied for longevity and cancer prevention effects.

LongevityAnti-AgingCancer-inhibitor
dose range
1–6 mg
Weekly or daily depending on indication and monitoring.
Consumption
Take orally, consistently with or without food, but avoid high-fat meals that can increase absorption; monitor blood levels if prescribed.
Fat-soluble: take with fat.
Best time
Immunosuppression regimens typically use daily dosing; longevity research often involves intermittent weekly dosing, which is not FDA-approved.

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Description

Rapamycin, also known as sirolimus, is a macrolide compound developed as an immunosuppressive drug for organ transplantation and is now widely researched for its effects on aging and cancer through inhibition of the mTOR pathway.

benefits
Main effects with level of evidence
Moderate
Note on evidence

Strong evidence for immunosuppression, emerging but promising data for longevity and mixed data for cancer prevention.

Extends lifespan in animal models

Moderate

Rapamycin has consistently extended lifespan in mice and other model organisms through inhibition of the mTOR pathway, suggesting potential anti-aging effects.

Particularly relevant for: Adults interested in longevity research
src1 · Harrison DE, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.src7 · Blagosklonny MV. Rapamycin for longevity: opinion article.

Prevents organ transplant rejection

Strong

Rapamycin suppresses T-cell activation, significantly reducing the risk of organ rejection after transplantation.

Particularly relevant for: Organ transplant patients
src2 · NIH: Sirolimus (Rapamycin) Drug Informationsrc5 · US Food and Drug Administration (FDA): Rapamune Prescribing Informationsrc8 · NIH: MedlinePlus - Sirolimus

May reduce cancer cell proliferation in some cancers

Moderate

Rapamycin and its analogs (rapalogs) can slow the growth of certain cancers, such as renal cell carcinoma, by inhibiting the mTOR pathway.

Particularly relevant for: Cancer patients with specific indications
src3 · Chiarini F, et al. The mTOR pathway and cancer therapy.src5 · US Food and Drug Administration (FDA): Rapamune Prescribing Information

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This information is for educational purposes only and does not replace medical advice.
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