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Saccharomyces
boulardii

Strong study situation·10/10
A higher score indicates better study conditions, but not necessarily effectiveness.

Saccharomyces boulardii is a probiotic yeast used to support gut health and manage diarrhea.

Digestion & Gut HealthImmune BoosterProbioticAntidiarrheal
dose range
250–1000 mg
1–2 times daily
Consumption
Take with or shortly after meals for best tolerance. Do not mix with hot beverages above 40°C (104°F), which may inactivate the yeast.
Not fat-soluble.
Best time
Often taken with meals; can be taken at any time of day.

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Description

Saccharomyces boulardii is a beneficial yeast-based probiotic, distinct from bacterial probiotics, commonly used for digestive health and prevention of certain types of diarrhea. It is well-studied for its role in supporting the intestinal barrier and modulating immune responses.

benefits
Main effects with level of evidence
Strong
Note on evidence

Extensive evidence supports S. boulardii for prevention and reduction of antibiotic-associated and infectious diarrhea; ongoing research for other gut and immune effects.

Reduces risk of antibiotic-associated diarrhea

Strong

Multiple clinical trials and meta-analyses show S. boulardii supplementation lowers the likelihood and severity of diarrhea during or following antibiotics.

Particularly relevant for: Individuals taking antibiotics · At risk for gut-related side effects
Cochrane_Hempel2012 · Cochrane Review — Hempel et al., 2012PubMed_Dizon2019 · PMID: 30721303 (Dizon et al., 2019)PubMed_McFarland2010 · PMID: 20061547 (McFarland, 2010)

Helps manage acute infectious diarrhea

Strong

Can reduce the duration and severity of infectious diarrhea, including in children and travelers, as supported by systematic reviews.

Particularly relevant for: General · Travelers · Children
NIH_FactSheet_SBoulardii_2022 · NIH Office of Dietary Supplements — Probiotics Fact SheetExamine_SBoulardii · Examine.com — Saccharomyces boulardii

Supports gut barrier function

Moderate

Evidence suggests S. boulardii may help maintain or restore the integrity of the intestinal barrier and reduce inflammatory cytokine responses.

Particularly relevant for: General · Gut health focus
PubMed_Hotel2001 · PMID: 11383522 (Hotel & Brot, 2001)PubMed_Szajewska2023 · PMID: 36924642 (Szajewska et al., 2023)

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This information is for educational purposes only and does not replace medical advice.
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This website is for educational and informational purposes only and does not constitute medical advice or professional services. The information provided should not be used to diagnose or treat any health problem or disease. Persons requiring medical advice should consult a licensed physician.
Saccharomyces boulardii: Benefits, Uses, Dosage – Numevo