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Arginine

Moderate study situation·7/10
A higher score indicates better study conditions, but not necessarily effectiveness.

L-Arginine is a conditionally essential amino acid supplement used to support cardiovascular health, tissue repair, and athletic performance.

Cardiovascular SupportTissue RepairEssential NutrientExercise PerformanceImmune Booster
dose range
2–10 g
Divided into 1–3 doses daily
Consumption
Take with or without food; pre-workout use is common for exercise support. Higher doses (10–30g) are reserved for clinical use under supervision.
Not fat-soluble.
Best time
May be taken in the morning, pre-workout, or post-workout. For ED, evening use is also common.

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Description

L-Arginine is an amino acid found in dietary protein and produced by the body, but supplementation can be beneficial during stress, illness, or for specific health goals. It is widely used for vascular function, wound healing, and exercise support.

benefits
Main effects with level of evidence
Moderate
Note on evidence

There is moderate evidence for L-Arginine’s effects on vascular health and erectile function, but benefits are more pronounced in deficiency, illness, or when used in clinical contexts.

Improves Blood Flow and Cardiovascular Health

Moderate

L-Arginine is a nitric oxide precursor, improving endothelial function and potentially lowering blood pressure, especially in people with hypertension or endothelial dysfunction.

Particularly relevant for: Adults with hypertension · Individuals at cardiovascular risk
2 · PubMed: Arginine and Endothelial Function5 · NIH Office of Dietary Supplements: Arginine Fact Sheet7 · American Journal of Clinical Nutrition: L-Arginine and Blood Pressure

Supports Erectile Function

Moderate

Supplementing L-Arginine can improve mild to moderate erectile dysfunction by enhancing blood flow to the genital area.

Particularly relevant for: Adults with ED
3 · PubMed: Arginine for Erectile Dysfunction5 · NIH Office of Dietary Supplements: Arginine Fact Sheet

Promotes Wound Healing and Tissue Repair

Moderate

L-Arginine supports collagen synthesis and immune function, aiding tissue repair and recovery in surgical and chronic wound patients.

Particularly relevant for: Individuals with chronic wounds · Surgical patients
4 · PubMed: Arginine in Wound Healing5 · NIH Office of Dietary Supplements: Arginine Fact Sheet8 · Cochrane Review: Oral arginine for treating chronic wounds

May Enhance Exercise Performance

Limited

Some evidence supports improved exercise capacity and reduced fatigue, although effects are modest in healthy, non-deficient adults.

Particularly relevant for: Athletes · Physically active adults
5 · NIH Office of Dietary Supplements: Arginine Fact Sheet6 · Examine.com: Arginine

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This information is for educational purposes only and does not replace medical advice.
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This website is for educational and informational purposes only and does not constitute medical advice or professional services. The information provided should not be used to diagnose or treat any health problem or disease. Persons requiring medical advice should consult a licensed physician.