Agnuside is an iridoid glycoside naturally found in chasteberry (Vitex agnus-castus). It is commonly used as a marker compound in standardized Vitex extracts.

What is Agnuside used for?

Agnuside-containing chasteberry extracts are most often used for premenstrual syndrome (PMS) symptoms such as breast tenderness and mood-related symptoms. They are also used for menstrual cycle support, with more limited evidence for menopausal symptoms.

How does Agnuside work?

It is studied for effects related to prolactin regulation and dopaminergic pathways, which may influence PMS symptoms. The overall effects likely reflect the combined activity of multiple compounds in Vitex extracts.

What is a typical Agnuside dosage?

A commonly referenced supplemental range is about 0.5–1 mg of agnuside per day, typically as part of a standardized chasteberry extract. Product potency varies, so check the label for agnuside content.

Is Agnuside safe for everyone?

It may not be appropriate during pregnancy or breastfeeding, and caution is advised with hormone-related conditions or medications that affect dopamine or hormones. Consult a clinician if you have medical conditions or take prescription medicines.

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Agnuside

Moderate study situation·7/10

A higher score indicates better study conditions, but not necessarily effectiveness.

Agnuside is a bioactive compound from chasteberry (Vitex agnus-castus) studied for women's hormonal health, especially PMS support.

PCOS Menopause Support Female Fertility Hormone Balance

dose range

0.5–1 mg

Once daily

Consumption

Take with or without food, preferably in the morning, as part of a standardized Vitex extract.

Not fat-soluble.

Best time

Consistent daily use, often in the morning, is preferred for hormonal support.

Description

Agnuside is an iridoid glycoside found in chasteberry, used in herbal medicine for PMS, menstrual, and menopausal symptoms. It acts as a key marker in standardized Vitex extracts.

benefits

Main effects with level of evidence

Moderate

Note on evidence

There is moderate-quality clinical evidence for benefits of agnuside-standardized Vitex extracts in PMS and cycle regulation, with fewer studies on menopausal symptoms.

Relief of Premenstrual Syndrome (PMS) Symptoms

Moderate

May reduce PMS symptoms such as irritability, breast tenderness, and mood swings via effects on prolactin and dopaminergic pathways.

Particularly relevant for: women with PMS

1 · PubMed – Vitex for PMS review 4 · NIH NCCIH – Chasteberry Fact Sheet

Support for Menstrual Cycle Regularity

Moderate

Agnuside-containing chasteberry extracts may help normalize irregular menstrual cycles in some women.

Particularly relevant for: women with irregular cycles

2 · WebMD – Vitex agnus-castus monograph 4 · NIH NCCIH – Chasteberry Fact Sheet

Eases Menopausal Symptoms

Limited

May provide mild relief from menopausal symptoms such as hot flashes and sleep problems, though evidence is more limited.

Particularly relevant for: perimenopausal and menopausal women

3 · PubMed – Vitex and menopausal symptoms study 2 · WebMD – Vitex agnus-castus monograph

Safety & Information

Important safety information & known risks

For educational purposes only • not medical advice

Generally well-tolerated when used at recommended doses in healthy adults, but has specific contraindications.

warning notices

Mild GI symptoms, headache, and allergic reactions are possible.
High-risk groups include pregnant and breastfeeding women, and those with hormone-sensitive cancers.
Avoid use during pregnancy due to possible hormonal effects.
Avoid use if you have hormone-sensitive conditions such as breast, uterine, or ovarian cancer.
Use only under medical supervision if taking dopaminergic drugs or medications affecting hormones.
Avoid during breastfeeding as safety has not been established.

Known interactions with medications