What is Flavonglykoside?

Flavonglykoside refers to flavone glycosides, a subgroup of flavonoids where a flavone is bound to a sugar molecule. They occur naturally in many plants and contribute to antioxidant activity.

What are the main benefits of flavone glycosides?

They are best known for antioxidant and anti-inflammatory effects and may support cardiovascular health by helping maintain healthy blood vessel function. Benefits depend on the specific compound and overall diet.

Which foods and supplements contain Flavonglykoside?

They are found in many fruits and vegetables, with notable sources including citrus-derived extracts. Some herbal supplements, such as Ginkgo biloba extracts, also contain flavonoid glycosides.

Is there a recommended dosage for Flavonglykoside supplements?

There is no single standard dose for all flavone glycosides because products vary widely in composition and concentration. Follow the product label and consider medical advice if you have health conditions or take medications.

Are flavone glycosides safe and do they interact with medications?

Food sources are generally considered safe for most people. Concentrated supplements may interact with certain medications depending on the extract (for example, some herbal products can affect blood thinning), so check with a clinician if unsure.

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Flavonglykoside

Moderate study situation·7/10

A higher score indicates better study conditions, but not necessarily effectiveness.

Flavonglycosides are plant-derived antioxidant compounds found in many fruits, vegetables, and herbal supplements, best known for their anti-inflammatory and cardiovascular benefits.

Anti-inflammatory Cardiovascular Support Antioxidant Immune Booster

dose range

0–0

Varies by compound or supplement; follow specific product directions or typical intake from diet.

Consumption

Best obtained from a varied diet rich in fruits, vegetables, and plant-based foods; follow supplement label instructions if used.

Not fat-soluble.

Best time

No specific timing required; can be taken at any time of day, with or without meals.

Description

Flavonglycosides (flavone glycosides) are a subgroup of flavonoids, occurring naturally in plants as antioxidants and commonly found in foods and some supplements such as Ginkgo biloba and citrus extracts.

benefits

Main effects with level of evidence

Moderate

Note on evidence

Benefits are supported by preclinical studies and some human trials; evidence strength depends heavily on the specific flavonglycoside and health outcome.

Antioxidant activity

Strong

Flavonglycosides act as antioxidants, helping neutralize free radicals and potentially reducing oxidative stress-related cellular damage.

Particularly relevant for: General population · Cardiovascular support · Healthy aging

NIH-ODS-Flavonoids · NIH Office of Dietary Supplements: Flavonoids PubMed-Review-2017 · Flavonoids: An Overview PMID-30641957 · Health benefits of flavonoids: A review

Supports cardiovascular health

Moderate

Dietary intake of flavonglycosides is associated with lower risk markers for cardiovascular disease, possibly due to improved endothelial function and blood vessel health.

Particularly relevant for: Cardiovascular support · General population

NIH-ODS-Flavonoids · NIH Office of Dietary Supplements: Flavonoids EFSA-Flavonoids · EFSA Scientific Opinion on Flavonoids PubMed-Review-2017 · Flavonoids: An Overview

Anti-inflammatory effects

Moderate

Some flavonglycosides modulate inflammatory pathways and may help reduce markers of inflammation.

Particularly relevant for: Immune Booster · General population

PMID-30641957 · Health benefits of flavonoids: A review PubMed-Review-2017 · Flavonoids: An Overview

Immune system support

Limited

Flavonglycosides may help modulate immune function, possibly increasing resistance to some infections and supporting immune response.

Particularly relevant for: Immune Booster · General population

Examine-Flavonoids · Examine.com: Flavonoids PubMed-Review-2017 · Flavonoids: An Overview

Safety & Information

Important safety information & known risks

For educational purposes only • not medical advice

Generally safe from food sources, but high-dose supplements may pose risks in specific populations.

warning notices

Excessive intake from supplements may increase risk of bleeding, especially with anticoagulant use.
Potential liver toxicity has been reported with very high doses or adulterated supplements.
Pregnant and breastfeeding individuals should use supplements only under supervision.
Avoid high-dose supplementation if you are taking anticoagulant or antiplatelet drugs, as bleeding risk may increase.
Use caution and consult a clinician before use if you have liver disease or impaired liver function.
Do not use concentrated flavonglycoside supplements during pregnancy or breastfeeding unless approved by a clinician.

Known interactions with medications

Anticoagulants (e.g., warfarin, aspirin)
Immunosuppressants (e.g., cyclosporine)

Contraindications / special precautions

History of significant bleeding disorders
Liver disease or impaired hepatic function

interactions

Important interactions between active ingredient ↔ supplement / medication / food

Flavonglycosides may interact with blood-thinning drugs and affect metabolism of certain medications.

Flavonglycosides may increase bleeding risk when combined with warfarin or similar anticoagulants.

drug · Warfarin

MonitorModerate

Why

Some flavonglycosides can inhibit platelet function or alter drug metabolism, increasing bleeding risk.

recommendation

Monitor INR closely and consult a healthcare provider before combining.

NIH-ODS-Flavonoids · NIH Office of Dietary Supplements: Flavonoids EFSA-Flavonoids · EFSA Scientific Opinion on Flavonoids

Some flavonglycosides may affect metabolism of cyclosporine and other drugs processed by CYP enzymes.

drug · Cyclosporine

CautionLimited

Why

Certain flavonglycosides can inhibit cytochrome P450 enzymes, potentially increasing drug levels.

recommendation

Use caution and consult a healthcare provider before combining supplements with cyclosporine or similar drugs.

NIH-ODS-Flavonoids · NIH Office of Dietary Supplements: Flavonoids PubMed-Review-2017 · Flavonoids: An Overview

mechanisms of action

Brief explanations of how it works

Antioxidant defense

Flavonglycosides scavenge free radicals and chelate metal ions, protecting against oxidative damage.

NIH-ODS-Flavonoids · NIH Office of Dietary Supplements: Flavonoids PubMed-Review-2017 · Flavonoids: An Overview

Vascular protection

They support endothelial function and may improve blood vessel flexibility, reducing cardiovascular risk.

PubMed-Review-2017 · Flavonoids: An Overview EFSA-Flavonoids · EFSA Scientific Opinion on Flavonoids

Inflammation modulation

Flavonglycosides can inhibit pro-inflammatory enzymes and cytokines, dampening inflammatory pathways.

PMID-30641957 · Health benefits of flavonoids: A review

Sources & References

Primary literature and reviews on which these statements are based

6 sources

NIH-ODS-Flavonoids

NIH Office of Dietary Supplements: Flavonoids

Examine-Flavonoids

Examine.com: Flavonoids

PubMed-Review-2017

Flavonoids: An Overview

Ginkgo-Flavonglycosides-NIH

NIH NCCIH: Ginkgo Biloba

Ginkgo biloba is a major supplement source of flavonglycosides.

PMID-30641957

Health benefits of flavonoids: A review

EFSA-Flavonoids

EFSA Scientific Opinion on Flavonoids

Laatst bijgewerkt: 6 februari 2026

This information is for educational purposes only and does not replace medical advice.