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Histidine

Moderate study situation·7/10
A higher score indicates better study conditions, but not necessarily effectiveness.

Semi-essential amino acid crucial for protein synthesis, histamine production, and nerve protection, with roles in immune function and kidney health.

Anti-inflammatoryEssential NutrientAntioxidantImmune BoosterNeuroprotectiveKidney HealthAnemia Support
dose range
500–1500 mg
Divide into 2–3 doses if over 1,500 mg/day or for therapeutic uses.
Consumption
Take orally; does not require fat for absorption; may be taken with or without food.
Not fat-soluble.
Best time
Can be taken at any time, typically with morning or main meals to support absorption and adherence.

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Description

Histidine is a semi-essential amino acid found in protein-rich foods and is vital for growth, tissue repair, and producing histamine. It is essential in children, certain health conditions, and during periods of physiological stress.

benefits
Main effects with level of evidence
Moderate
Note on evidence

Strongest clinical evidence for therapeutic dosing in kidney disease–related anemia; moderate for other benefits; generally safe at typical intakes.

Supports immune function and histamine production

Moderate

Acts as a precursor to histamine, involved in immune response regulation and allergy management.

Particularly relevant for: Individuals with immune dysfunction · General population
1 · Journal of Nutrition4 · NIH Office of Dietary Supplements: Protein and Amino Acids5 · Examine.com: Histidine

Promotes kidney health and anemia management

Strong

Supplementation may improve hemoglobin levels and anemia in people with chronic kidney disease.

Particularly relevant for: Individuals with chronic kidney disease · People with anemia
2 · American Journal of Clinical Nutrition

Provides antioxidant and neuroprotective effects

Limited

Acts as an antioxidant and helps protect nerve cells, possibly supporting neurological health.

Particularly relevant for: Individuals at risk of neurodegenerative conditions
3 · Amino Acids

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This information is for educational purposes only and does not replace medical advice.
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This website is for educational and informational purposes only and does not constitute medical advice or professional services. The information provided should not be used to diagnose or treat any health problem or disease. Persons requiring medical advice should consult a licensed physician.