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Hydroxylysine

Limited research available·3/10
A higher score indicates better study conditions, but not necessarily effectiveness.

Hydroxylysine is a collagen-specific amino acid crucial for connective tissue strength and structure.

Anti-AgingTissue RepairBone HealthSkin Health
dose range
100–500 mg
1-2 servings, often with meals
Consumption
Commonly taken as part of hydrolyzed collagen or amino acid supplements; standalone use is uncommon.
Not fat-soluble.
Best time
Likely best with the first meal due to protein metabolism; vitamin C co-ingestion may enhance benefit in collagen synthesis.

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Description

Hydroxylysine is a non-essential amino acid derived from the modification of lysine, predominantly found in collagen of connective tissues such as skin, bone, and cartilage. It supports the integrity and repair of these tissues and is produced in the body via a vitamin C-dependent process.

benefits
Main effects with level of evidence
Limited
Note on evidence

Direct human supplementation data is scarce; most evidence relates to hydroxylysine’s role in collagen structure and metabolism.

Supports bone health and strength

Limited

Hydroxylysine is integral to bone collagen cross-linking, which contributes to bone density and the prevention of fragility disorders.

Particularly relevant for: adults at risk of osteoporosis · those seeking improved bone integrity
3 · NIH

Promotes tissue repair and wound healing

Limited

Essential for the stabilization of collagen, hydroxylysine aids tissue regeneration and wound closure by supporting connective tissue matrix formation.

Particularly relevant for: individuals recovering from injury or surgery · aged populations
2 · Journal of Biological Chemistry

Enhances skin structure and elasticity

Limited

By contributing to collagen remodeling, hydroxylysine helps maintain skin firmness and may support anti-aging effects.

Particularly relevant for: adults concerned with skin aging · cosmetic dermatology patients
4 · International Journal of Molecular Sciences

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This information is for educational purposes only and does not replace medical advice.
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This website is for educational and informational purposes only and does not constitute medical advice or professional services. The information provided should not be used to diagnose or treat any health problem or disease. Persons requiring medical advice should consult a licensed physician.