What is Ketosterone (7-Keto DHEA)?

Ketosterone, also called 7-Keto DHEA, is a naturally occurring metabolite of DHEA. It is marketed as a non-hormonal option for metabolic and weight-management support.

Does Ketosterone convert to testosterone or estrogen?

7-Keto DHEA is generally described as not converting into sex hormones like testosterone or estrogen. This is one reason it is promoted as “non-hormonal” compared with DHEA.

What are the main benefits of Ketosterone?

It is most commonly used to support weight loss and metabolic rate, especially alongside diet and exercise. Some people also use it for energy, vitality, or healthy aging, though evidence is more limited for these uses.

What is a typical Ketosterone dosage?

Common supplemental amounts are 100–200 mg per day. Follow product directions and consider medical advice if you have health conditions or take medications.

What are possible side effects or precautions with Ketosterone?

Side effects can include stimulant-like effects such as restlessness or sleep changes in some people. Avoid use during pregnancy or breastfeeding, and consult a clinician if you have thyroid conditions, hormone-sensitive conditions, or are taking prescription medicines.

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Ketosterone

Limited research available·3/10

A higher score indicates better study conditions, but not necessarily effectiveness.

Ketosterone (7-Keto DHEA) is a non-hormonal DHEA metabolite used to support metabolism and weight management.

Longevity Anti-Aging Immune Booster Skin Health Weight Management

dose range

100–200 mg

Divided into two doses (morning and afternoon or with meals).

Consumption

Take with food to enhance absorption due to fat solubility.

Fat-soluble: take with fat.

Best time

Morning and mid-day dosing may be preferable as occasional reports of sleep disturbance with late-day intake.

Description

Ketosterone, also known as 7-Keto DHEA, is a naturally occurring metabolite of DHEA produced in the body. It does not convert to sex hormones and is marketed for weight loss, metabolic support, and anti-aging benefits.

benefits

Main effects with level of evidence

Limited

Note on evidence

Preliminary human studies and small clinical trials provide modest evidence for weight management and metabolic benefits. Larger and longer-term trials are lacking.

Supports Weight Loss

Limited

Supplementation with Ketosterone has been shown to modestly enhance weight loss and fat loss when combined with calorie restriction and exercise.

Particularly relevant for: Weight Management

1 · PubMed (Kalman et al. 2000): 7-Keto DHEA and weight loss 5 · Examine.com: 7-Keto DHEA

Boosts Metabolic Rate

Limited

May increase resting metabolic rate and thermogenesis, with some evidence pointing to enhanced fat oxidation and thyroid hormone (T3) activity without raising TSH.

Particularly relevant for: Longevity · Weight Management · Anti-Aging

2 · PubMed (Davidson et al. 2002): Metabolic effects of 7-Keto DHEA 5 · Examine.com: 7-Keto DHEA

May Support Immune Function

Limited

Animal and limited clinical evidence suggests a potential for improving immune response, especially under stress or aging, but data in humans are preliminary.

Particularly relevant for: Immune Booster · Anti-Aging

3 · WebMD: 7-Keto DHEA Overview 6 · Lin, Y., et al. (2002). 7-Keto DHEA and immune function. FASEB J.

May Support Vitality and Mood in Aging

Theoretical

Proposed to counter some effects of aging by modulating cortisol and supporting energy, though evidence remains mixed and mostly theoretical.

Particularly relevant for: Longevity · Anti-Aging

3 · WebMD: 7-Keto DHEA Overview 4 · NIH Office of Dietary Supplements: DHEA Fact Sheet

Safety & Information

Important safety information & known risks

For educational purposes only • not medical advice

Likely safe for healthy adults in typical doses for short periods; should not be used in certain populations.

warning notices

Mild side effects including nausea, dizziness, or headache are infrequent.
Potential for low blood pressure in sensitive individuals.
Serious adverse events are rare in clinical trials at recommended doses.
Should not be used during pregnancy, breastfeeding, or with active hormone-sensitive cancers or liver disease.
Avoid use if pregnant or breastfeeding.
Contraindicated in individuals with hormone-sensitive cancers or liver disease.
Monitor blood pressure in those with hypotension risk.
Use only under medical supervision if taking hormone-modulating medications.

Known interactions with medications

Corticosteroids
Hormone therapies

Contraindications / special precautions

Pregnancy
Breastfeeding
Hormone-sensitive cancers
Liver disease

interactions

Important interactions between active ingredient ↔ supplement / medication / food

Ketosterone is generally well tolerated but may interact with medications that modulate hormones or affect liver metabolism. It has modest potential to influence cortisol and thyroid hormones.