Best nutrients for Anxiety Relief

Evidence-ranked nutrients and supplements that may support Anxiety Relief. Explore each for benefits, dosage, safety and the underlying research.

32 nutrients

10/10Eicosapentaenoic acid (EPA)A long-chain omega-3 fatty acid from marine sources, proven to support heart health, reduce inflammation, and benefit mood.
9/10St. John’s Wort ExtractPlant extract most studied for alleviating mild to moderate depression, but with extensive drug interaction risks.
6/10Hops ExtractHops extract is an herbal supplement used mainly for sleep support, anxiety reduction, and menopausal symptom relief.
6/10Rhodiola Rosea ExtractRhodiola Rosea Extract is an adaptogenic herb used to help the body resist physical and mental stress, reduce fatigue, and support mood.
3/10L-TheanineL-Theanine is an amino acid from tea leaves, valued for promoting relaxation, reducing stress, and enhancing focus without sedation.
3/10Ashwagandha Root ExtractAshwagandha root extract is an adaptogenic herbal supplement shown to reduce stress, improve sleep, and support physical performance.
3/10Ginkgo BilobaHerbal supplement with evidence for supporting cognitive function in dementia and improving peripheral circulation; requires bleeding risk precautions.
3/10LysineLysine is an essential amino acid important for protein synthesis and immune function, with evidence for cold sore prevention and potential support for bone and mental health.
3/10Magnesium BisglycinateA chelated, highly bioavailable form of magnesium used for sleep, relaxation, and muscle support, with reduced gastrointestinal side effects.
3/10Vitamin B5 (Pantothenic Acid)Essential B vitamin involved in energy and fat metabolism, broadly found in foods and typically only supplemented for specific reasons.
3/10Vitamin B8 (Myo-Inositol)A naturally occurring nutrient often used as a supplement for metabolic, reproductive, and mental health.
3/10WithanolidesWithanolides are bioactive compounds in Ashwagandha, used for stress resilience, sleep improvement, and inflammation reduction.
3/10Gotu Kola ExtractTraditional Asian herbal extract used for cognitive support, wound healing, and vascular health.
3/10Valerian ExtractValerian extract is a plant-based supplement often used to improve sleep quality and relieve mild anxiety.
3/10BacopaHerbal nootropic traditionally used in Ayurveda, Bacopa supports memory, stress resilience, and brain antioxidant defenses.
3/10Lemon Balm ExtractLemon balm extract is a traditional herbal supplement used primarily for calming anxiety, improving sleep, and mild cognitive support.
3/10Basil ExtractBasil extract (especially Holy Basil/Tulsi) is a traditional herbal supplement shown to support stress reduction, inflammation control, and metabolic health.
3/10Chamomile ExtractChamomile extract is a popular herbal remedy known for promoting relaxation, sleep, and digestive comfort.
3/10Hericium Erinaceus ExtractHericium erinaceus (Lion’s Mane) extract is a fungus supplement with emerging evidence supporting cognitive, neuroprotective, and mood benefits.
3/10Lavender ExtractLavender extract is a herbal supplement commonly used to support relaxation, reduce anxiety, and improve sleep quality.
2/10ApigeninApigenin is a natural plant flavonoid studied for its antioxidant, anti-inflammatory, calming, and anticancer properties.
2/10LithiumorotateLithium orotate is an over-the-counter supplement providing low doses of lithium, marketed for mood and brain health, but requires caution due to potential toxicity.
2/10GABAGABA (gamma-aminobutyric acid) is a calming neurotransmitter, widely used as a supplement for relaxation, sleep quality, and stress support.
2/10Vervain ExtractBotanical extract with traditional use for mild anxiety, sleep, and inflammation; human evidence is limited.
2/10Aloysia triphyllaAloysia triphylla (Lemon Verbena) is a lemon-scented herb used in teas and supplements for digestive, anti-inflammatory, and calming effects, though robust clinical evidence remains limited.
2/10L-TryptophanL-Tryptophan is an essential amino acid supplement explored for supporting sleep and mood, with established safety risks and limited evidence for clinical depression.
2/10SelankSelank is a synthetic peptide with anxiolytic, cognitive-enhancing, and immunomodulatory effects, primarily studied in Russia for intranasal use.
2/10Magnesium (Taurate)Magnesium taurate is a chelated form of magnesium bound to taurine, often used for cardiovascular and nervous system support.
2/10Golden Poppy extractCalifornia poppy (Golden Poppy) extract is an herbal supplement traditionally used for mild sleep disturbances and stress relief.
1/10Gamma-Aminobutyric AcidA calming neurotransmitter supplement that may support relaxation, sleep, and healthy blood pressure.
Passionflower ExtractHerbal extract from Passiflora incarnata traditionally used for anxiety and sleep support with moderate evidence for calming effects.
BacosideBacosides, key compounds in Bacopa monnieri, support memory, cognition, stress resilience and brain health.

Last updated: July 25, 2026