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Citicoline (CDP-
Choline)

Moderate study situation·7/10
A higher score indicates better study conditions, but not necessarily effectiveness.

Citicoline (CDP-Choline) is a brain health supplement with evidence for cognitive enhancement and neuroprotection, especially post-stroke and in glaucoma.

Eye HealthCognitive EnhancementMemory ImprovementNeuroprotective
dose range
250–1000 mg
once or twice daily
Consumption
Orally, with or without food.
Not fat-soluble.
Best time
Morning dosing is common due to potential mild stimulatory effects. Divide doses for higher amounts.

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Description

Citicoline, also called CDP-Choline, is a choline compound used as a dietary supplement for cognitive and neuroprotective purposes. It is a precursor to phosphatidylcholine and acetylcholine, supporting cell membranes and neurotransmitter function.

benefits
Main effects with level of evidence
Moderate
Note on evidence

Evidence for cognitive benefits and neuroprotection is strongest in populations with neurological impairment, with mixed but promising results in healthy adults.

Cognitive Enhancement

Moderate

Supplementation may improve memory, attention, and mental processing—especially in individuals with mild cognitive impairment or recovering from stroke.

Particularly relevant for: Older adults · Individuals with cognitive impairment · Post-stroke patients
1 · Citicoline improves cognitive performance in patients with chronic cerebral disorders: a meta-analysis2 · Citicoline in acute ischemic stroke: a systematic review and meta-analysis

Support in Stroke Recovery

Moderate

May aid neurological and functional recovery when used early after ischemic stroke, as an adjunct to standard therapy.

Particularly relevant for: Post-stroke patients
2 · Citicoline in acute ischemic stroke: a systematic review and meta-analysis6 · Citicoline: update on a neuroprotective agent

Neuroprotection in Glaucoma

Limited

May help slow progression of visual field loss and improve retinal function in glaucoma, especially as adjunctive therapy.

Particularly relevant for: Adults with glaucoma
3 · Neuroprotective effects of citicoline in glaucoma patients

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This information is for educational purposes only and does not replace medical advice.
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