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Nicotinamide
Riboside

Moderate study situation·7/10
A higher score indicates better study conditions, but not necessarily effectiveness.

Nicotinamide riboside (NR) is a vitamin B3 derivative that acts as a precursor to NAD+, supporting cellular energy, metabolism, and healthy aging.

LongevityAnti-AgingCognitive EnhancementEssential NutrientNeuroprotectiveWeight Management
dose range
100–1000 mg
1–2 divided doses daily
Consumption
Take with or without food; morning or with first meal is common to align with metabolic demands.
Not fat-soluble.
Best time
Consistency may help maintain NAD+ levels. Higher doses should be assessed for tolerability.

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Description

Nicotinamide riboside is a naturally occurring form of vitamin B3 found in trace amounts in foods and used as a supplement to elevate NAD+ levels, which play critical roles in cell function, aging, and metabolism.

benefits
Main effects with level of evidence
Moderate
Note on evidence

Human trials consistently show NR increases NAD+ levels and is safe up to 1000 mg/day, but evidence for disease-related outcomes is promising yet preliminary.

Supports Healthy Aging and Cellular Repair

Moderate

Supplementing with NR elevates NAD+ levels, which may enhance DNA repair, improve mitochondrial function, and help counteract age-related cellular decline.

Particularly relevant for: adults · older adults
S1 · Elhassan, Y.S. et al. Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures.S2 · Trammell, S.A.J., et al. Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice and Increases NAD+ Metabolites in Humans.

Promotes Metabolic Health and Energy Metabolism

Moderate

NR may improve metabolic function, insulin sensitivity, and mitochondrial health by boosting NAD+ status, with some human evidence for improved energy metabolism.

Particularly relevant for: adults · those interested in weight management or metabolic health
S1 · Elhassan, Y.S. et al. Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures.S2 · Trammell, S.A.J., et al. Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice and Increases NAD+ Metabolites in Humans.S7 · Canto, C., Menzies, K.J., Auwerx, J. NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus.

Potential Neuroprotection

Limited

Animal studies and early human trials suggest NR may support neuronal health and could help protect against age-related neurodegeneration.

Particularly relevant for: older adults · those at risk for neurodegenerative disease
S3 · Vaur, P. et al. NR supplementation results in neuroprotection in mouse models of Alzheimer's disease and in healthy humans.

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This information is for educational purposes only and does not replace medical advice.
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This website is for educational and informational purposes only and does not constitute medical advice or professional services. The information provided should not be used to diagnose or treat any health problem or disease. Persons requiring medical advice should consult a licensed physician.