What does Vitamin B2 (riboflavin) do in the body?

Riboflavin helps convert carbohydrates, fats, and proteins into usable energy by forming the coenzymes FMN and FAD. It also supports antioxidant systems and normal skin, eye, and nervous system function.

Can riboflavin help prevent migraines?

High-dose riboflavin is commonly used for migraine prevention in adults and may reduce migraine frequency for some people. It typically needs consistent daily use for several weeks to assess benefit.

What are common signs of riboflavin deficiency?

Deficiency can cause cracks at the corners of the mouth, sore throat, inflamed tongue, and skin changes. It may also contribute to fatigue and other symptoms related to impaired energy metabolism.

What foods are high in Vitamin B2 (riboflavin)?

Riboflavin is found in dairy products, eggs, lean meats, fish, leafy greens, legumes, and fortified cereals. Because it is water-soluble, regular dietary intake is important.

How much riboflavin should I take?

Needs vary by age and life stage, but typical adult requirements are around 1–1.3 mg per day from diet and supplements. Higher doses are sometimes used for specific goals such as migraine prevention under clinician guidance.

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Vitamin B2
(Riboflavin)

Strong study situation·10/10

A higher score indicates better study conditions, but not necessarily effectiveness.

Water-soluble B vitamin crucial for energy metabolism, cellular health, and migraine prevention.

Eye Health Essential Nutrient Antioxidant Skin Health Anemia Support Energy Support Migraine Support

dose range

1.1–400 mg

once daily (RDA); for migraine, often 400 mg as single daily dose

Consumption

Take with or after meals to improve absorption and minimize gastrointestinal discomfort. Store supplements away from light due to light-sensitivity.

Not fat-soluble.

Best time

Riboflavin can be taken at meals; divide doses over meals for high-dose regimens to enhance tolerability.

Description

Vitamin B2 (riboflavin) is essential for cellular energy production and metabolic processes. It participates in key enzymatic reactions that help convert food into usable energy, supports antioxidant mechanisms, and plays a role in vision, skin, and nervous system health.

benefits

Main effects with level of evidence

Strong

Note on evidence

Riboflavin’s essentiality and roles are well established, with robust evidence for deficiency symptoms and select therapeutic uses.

Supports Energy Production and Metabolism

Strong

Riboflavin is a precursor to coenzymes (FMN, FAD) required for electron transport and ATP synthesis in mitochondria, facilitating energy conversion from carbohydrates, fats, and proteins.

Particularly relevant for: Adults · Athletes

NIH · National Institutes of Health Office of Dietary Supplements: Riboflavin Fact Sheet ClevelandClinic · Cleveland Clinic: Riboflavin (Vitamin B2)EFSA · EFSA Panel on Dietetic Products, Nutrition and Allergies. 'Scientific Opinion on the substantiation of health claims related to riboflavin.' EFSA Journal. 2010;8(10):1747.

Migraine Prevention (High-Dose)

Moderate

Supplementation with 400 mg/day riboflavin has been shown in clinical trials to reduce migraine frequency and severity in adults.

Particularly relevant for: Migraine Sufferers

OlesenMigraine1997 · Olesen J, et al. 'Riboflavin as a prophylactic treatment for migraine.' Cephalalgia. 1997 Aug;17(5):673-6.NIH · National Institutes of Health Office of Dietary Supplements: Riboflavin Fact Sheet

Supports Eye Health and May Lower Risk of Cataracts

Moderate

Higher riboflavin intake is associated with lower risk of developing cataracts, possibly due to its role in maintaining antioxidant status in the eye.

Particularly relevant for: Older Adults · People at Risk of Cataracts

NIH · National Institutes of Health Office of Dietary Supplements: Riboflavin Fact Sheet EFSA · EFSA Panel on Dietetic Products, Nutrition and Allergies. 'Scientific Opinion on the substantiation of health claims related to riboflavin.' EFSA Journal. 2010;8(10):1747.

Assists in Iron Metabolism and May Help Prevent Anemia

Moderate

Riboflavin deficiency impairs iron absorption and utilization; adequate intake can support red blood cell production and prevent or improve anemia, especially in at-risk populations.

Particularly relevant for: Pregnant Women · Children · Vegetarians

NIH · National Institutes of Health Office of Dietary Supplements: Riboflavin Fact Sheet ClevelandClinic · Cleveland Clinic: Riboflavin (Vitamin B2)

Maintains Healthy Skin and Mucous Membranes

Strong

Riboflavin is necessary for tissue repair and protects against symptoms like mouth cracks and skin inflammation.

Particularly relevant for: General Population

NIH · National Institutes of Health Office of Dietary Supplements: Riboflavin Fact Sheet Healthline · Healthline: Riboflavin — Benefits, Sources, Deficiency

Safety & Information

Important safety information & known risks

For educational purposes only • not medical advice

Riboflavin is considered safe; no toxicity reported at high oral intakes. High doses can cause harmless yellow urine.

warning notices

No adverse effects observed from daily supplemental intakes up to 400 mg in studies.
High-dose supplementation should be used under medical supervision, especially in pregnancy and with chronic diseases.
Riboflavin is excreted via the urine; excess amounts are not stored.
Do not use high-dose riboflavin supplements (>100 mg/day) for extended periods without medical supervision in pregnancy or active malignancy.
People taking certain antimalarial or cancer drugs should consult their healthcare provider before using riboflavin supplements due to potential drug interactions.

Known interactions with medications

May interact with certain antimalarial and chemotherapy drugs.

Contraindications / special precautions

Use high-dose supplements cautiously in pregnancy and cancer unless advised by a healthcare provider.

interactions

Important interactions between active ingredient ↔ supplement / medication / food

Riboflavin has few significant interactions, but some medications may lower its status or be affected by supplementation.

Some antimalarial medications may lower riboflavin levels.

drug · Antimalarial drugs (e.g., primaquine)

CautionModerate

Why

Certain drugs can increase riboflavin metabolism, potentially causing deficiency.

recommendation

Monitor for deficiency signs if using long-term antimalarial therapy, and supplement if directed by a clinician.

NIH · National Institutes of Health Office of Dietary Supplements: Riboflavin Fact Sheet

Some chemotherapy drugs may deplete riboflavin.

drug · Cancer chemotherapy agents (e.g., doxorubicin)

CautionLimited

Why

Chemotherapy can affect B-vitamin levels, including riboflavin, due to increased metabolic demand or loss.

recommendation

Discuss supplementation with your oncology team if undergoing chemotherapy.

NIH · National Institutes of Health Office of Dietary Supplements: Riboflavin Fact Sheet

mechanisms of action

Brief explanations of how it works

Coenzyme Function (FAD and FMN) in Energy Metabolism

Riboflavin forms FMN and FAD, which are required for oxidation-reduction reactions in cellular energy production.

Antioxidant Regeneration

Riboflavin is needed to regenerate glutathione, a key cellular antioxidant, thereby supporting body redox balance.

NIH · National Institutes of Health Office of Dietary Supplements: Riboflavin Fact Sheet

Support of Iron Metabolism

Riboflavin promotes iron absorption and integration into hemoglobin, aiding prevention of anemia.

NIH · National Institutes of Health Office of Dietary Supplements: Riboflavin Fact Sheet

Sources & References

Primary literature and reviews on which these statements are based

7 sources

NIH

National Institutes of Health Office of Dietary Supplements: Riboflavin Fact Sheet

ClevelandClinic

Cleveland Clinic: Riboflavin (Vitamin B2)

MountSinai

Mount Sinai: Riboflavin (Vitamin B2)

Healthline

Healthline: Riboflavin — Benefits, Sources, Deficiency

WebMD

WebMD: Riboflavin (Vitamin B2)

OlesenMigraine1997

Olesen J, et al. 'Riboflavin as a prophylactic treatment for migraine.' Cephalalgia. 1997 Aug;17(5):673-6.

Randomized clinical trial on migraine prevention.

EFSA

EFSA Panel on Dietetic Products, Nutrition and Allergies. 'Scientific Opinion on the substantiation of health claims related to riboflavin.' EFSA Journal. 2010;8(10):1747.

Laatst bijgewerkt: 13 februari 2026

This information is for educational purposes only and does not replace medical advice.