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Guggulsterone

Limited research available·3/10
A higher score indicates better study conditions, but not necessarily effectiveness.

Guggulsterone is a plant-derived compound studied for cholesterol management, anti-inflammatory, and potential thyroid-modulating effects.

Anti-inflammatoryCardiovascular SupportLiver HealthCholesterol Management
dose range
50–150 mg/day
Divided into 2-3 doses daily
Consumption
Take with or without food; use only standardized extracts.
Not fat-soluble.
Best time
Consistent timing daily may reduce side effects.

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Description

Guggulsterone is a bioactive sterol found in the gum resin of Commiphora mukul (guggul). Traditionally used in Ayurvedic medicine, it is now marketed as a supplement for cholesterol and metabolic health.

benefits
Main effects with level of evidence
Limited
Note on evidence

Human evidence for cholesterol and inflammation benefits is inconsistent, and safety concerns exist regarding liver health and thyroid effects.

Supports healthy cholesterol levels

Limited

Guggulsterone may modestly lower total and LDL cholesterol, though results are mixed and larger, recent trials do not confirm consistent effects.

Particularly relevant for: Adults with high cholesterol
nih-ods-guggul · NIH Office of Dietary Supplements: Guggulnccih-guggul · National Center for Complementary and Integrative Health (NCCIH): Guggulexamine-guggulsterone · Examine.com: Guggulsterone

May have anti-inflammatory effects

Limited

Laboratory and animal studies suggest anti-inflammatory properties; however, human data are sparse and not robust.

Particularly relevant for: Adults with chronic inflammation
pubmed-vd-guggul-review · PubMed: Verma & Deshmukh, Guggul Reviewexamine-guggulsterone · Examine.com: Guggulsterone

Potential thyroid-modulating effect

Limited

Guggulsterone may increase thyroid hormone activity, which could alter metabolic rate, but clinical evidence in humans is weak.

Particularly relevant for: Individuals with thyroid disorders (under supervision only)
examine-guggulsterone · Examine.com: Guggulsteronepubmed-guggulsterone-effects · PubMed: Guggulsterone Effects

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This information is for educational purposes only and does not replace medical advice.
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This website is for educational and informational purposes only and does not constitute medical advice or professional services. The information provided should not be used to diagnose or treat any health problem or disease. Persons requiring medical advice should consult a licensed physician.