Withanolides
Withanolides are bioactive compounds in Ashwagandha, used for stress resilience, sleep improvement, and inflammation reduction.
Withanolides are steroidal lactones and the principal active constituents in Ashwagandha (Withania somnifera), long used in Ayurvedic medicine for their adaptogenic and restorative effects. Standardized extracts containing withanolides are increasingly studied for stress, mood, immune function, and other health benefits.
There is moderate quality evidence from randomized trials and systematic reviews for stress and mild anxiety reduction, with limited but growing evidence for sleep quality, anti-inflammatory effects, and other benefits.
Stress and Anxiety Reduction
ModerateSupplementation with withanolides, as standardized Ashwagandha extract, significantly lowers cortisol and perceived stress while offering mild anxiety relief in adults under chronic stress.
Sleep Improvement
LimitedWithanolides may improve sleep quality and reduce sleep onset latency, particularly in people with stress-related or mild insomnia.
Anti-inflammatory and Antioxidant Support
LimitedWithanolides demonstrate anti-inflammatory effects by modulating cytokines and possess antioxidant properties, which may support immune health and reduce markers of chronic inflammation.
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