Proferrin is an oral heme iron polypeptide (HIP) supplement derived from bovine hemoglobin. It provides elemental iron in a heme form designed for efficient absorption.

What is Proferrin used for?

It is used to help treat iron deficiency and iron deficiency anemia by supporting hemoglobin and iron stores such as ferritin. It may be considered when non-heme iron supplements are not well tolerated or effective.

How much Proferrin should I take?

Common supplemental dosing provides about 11–33 mg of elemental iron per day, depending on individual needs and product strength. Follow the product label and clinician guidance, especially if you have anemia or chronic conditions.

Does Proferrin cause fewer stomach side effects than other iron supplements?

Many people report fewer gastrointestinal effects such as constipation, nausea, or stomach discomfort compared with traditional iron salts. Individual tolerance can vary.

Who should be cautious with Proferrin?

People with iron overload disorders or those advised to avoid iron should not use it unless directed by a clinician. Because it is bovine-derived, it may not be suitable for individuals avoiding animal products or with specific allergies.

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Proferrin

Moderate study situation·7/10

A higher score indicates better study conditions, but not necessarily effectiveness.

Proferrin is a highly bioavailable, bovine-derived heme iron supplement for treating iron deficiency with fewer gastrointestinal side effects than traditional iron salts.

Essential Nutrient Kidney Health Anemia Support

dose range

11–33 mg

1–3 times per day

Consumption

Take with meals for optimal tolerability; dosing should be adjusted by a healthcare provider based on iron levels and clinical response.

Not fat-soluble.

Best time

Best taken with the first and/or second main meal. Avoid taking alongside high-calcium foods or certain antibiotics.

Description

Proferrin contains heme iron polypeptide (HIP), a source of elemental iron derived from bovine hemoglobin, designed to efficiently improve iron status and treat anemia in individuals who may not tolerate or absorb non-heme iron well.

benefits

Main effects with level of evidence

Moderate

Note on evidence

Clinical trials and comparative data support its efficacy and tolerability, though meta-analyses and long-term safety data are limited.

Improves iron deficiency anemia

Moderate

Effectively increases hemoglobin and ferritin levels in patients with iron deficiency, often with better absorption and tolerability than ferrous salts.

Particularly relevant for: Individuals with iron deficiency anemia · Women with heavy menstrual periods

3 · PubMed: Oral heme iron polypeptide in women with iron deficiency anemia

Fewer gastrointestinal side effects

Moderate

Associated with less constipation, nausea, and stomach discomfort versus traditional iron supplements, leading to better adherence.

Particularly relevant for: People with GI sensitivity to iron · Older adults

1 · WebMD: Heme Iron Polypeptide 3 · PubMed: Oral heme iron polypeptide in women with iron deficiency anemia

Effective in chronic health conditions

Moderate

Remains well-absorbed and effective for managing anemia in patients with chronic kidney disease, IBD, or poor absorption from non-heme sources.

Particularly relevant for: CKD patients · Individuals with IBD

2 · NIH ODS: Iron Fact Sheet for Health Professionals 4 · PubMed: Efficacy of heme iron polypeptide for anemia in CKD patients

Safety & Information

Important safety information & known risks

For educational purposes only • not medical advice

Generally well-tolerated, but risks of iron overload, allergic reactions, or drug interactions exist in sensitive groups.

warning notices

Monitor for symptoms of iron overload with prolonged use.
Allergy risk for those with bovine protein sensitivities.
Mild GI side effects may occur, but are less common than with other iron forms.
Contraindicated in hereditary hemochromatosis and some anemias.
Drug interactions with some antibiotics require dose separation.
Contraindicated in individuals with hemochromatosis or other iron overload conditions.
Avoid use if allergic to bovine proteins.
Do not take with tetracycline antibiotics due to impaired absorption for both medications.
Monitor iron levels regularly to avoid iron overload, especially in chronic disease.
Caution in individuals with hemolytic anemia; use only with clinician supervision.

Known interactions with medications

Tetracyclines

Contraindications / special precautions

Hemochromatosis
Hemolytic anemia
Bovine protein allergy

interactions

Important interactions between active ingredient ↔ supplement / medication / food

Proferrin's absorption is not significantly hindered by typical dietary inhibitors, but some drugs and nutrients can affect absorption or effectiveness.