What is manganese (bisglycinate)?

Manganese (bisglycinate) is manganese chelated to two glycine molecules. This form is designed to improve absorption and gastrointestinal tolerance compared with some inorganic forms.

What are the main benefits of manganese (bisglycinate)?

It supports bone and cartilage formation, helps antioxidant defenses via manganese superoxide dismutase (MnSOD), and contributes to normal metabolism of carbohydrates, amino acids, and cholesterol.

How much manganese (bisglycinate) is typically taken?

Common supplemental amounts are about 2–5 mg of elemental manganese per day. Needs vary based on diet, age, and health status.

Who should be cautious with manganese supplements?

People with liver disease or impaired bile excretion should use caution because manganese is cleared mainly through bile. Those taking multiple mineral products should also avoid excessive total intake.

Can manganese (bisglycinate) be taken with other minerals?

Yes, but minerals can compete for absorption when taken together. If you use iron, calcium, or zinc supplements, consider separating doses to reduce competition.

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Manganese
(Bisglycinate)

Moderate study situation·7/10

A higher score indicates better study conditions, but not necessarily effectiveness.

Highly bioavailable form of the essential trace mineral manganese, supporting bone health, metabolism, and antioxidant defenses.

Essential Nutrient Antioxidant Bone Health Glucose Metabolism

dose range

2–5 mg

1-2 doses with meals

Consumption

Take with food to improve absorption and reduce stomach upset; do not exceed 11 mg per day from all dietary and supplemental sources unless supervised.

Not fat-soluble.

Best time

Best taken with meals, in the morning or at the first meal of the day.

Description

Manganese (Bisglycinate) is a chelated form of the trace mineral manganese, designed to improve absorption and gastrointestinal tolerance. Manganese is vital for several biological processes including enzymatic reactions, antioxidant activity, bone formation, and metabolism. Manganese bisglycinate supplements may help meet increased needs or address dietary shortfalls more effectively than inorganic forms.

benefits

Main effects with level of evidence

Moderate

Note on evidence

Benefits of manganese for bone health and antioxidant defense are well-supported; stronger research is needed on specific outcomes of the bisglycinate form.

Supports bone health and formation

Moderate

Contributes to bone matrix synthesis, cartilage health, and may help reduce fracture risk in deficient populations.

Particularly relevant for: Older adults · Postmenopausal women · Individuals with poor diets

S2 · Nutrients (2019): Impact of various aspects of manganese on bone and cartilage health S6 · EFSA Journal (2013): Scientific Opinion on Dietary Reference Values for Manganese S7 · Linus Pauling Institute: Manganese

Enhances antioxidant defense

Moderate

Acts as a cofactor in manganese superoxide dismutase (MnSOD), protecting cells from oxidative stress.

Particularly relevant for: Adults · Aging population · Those with chronic disease risk

S3 · Free Radical Biology and Medicine (2009): MnSOD, oxidative stress, and mitochondrial health S7 · Linus Pauling Institute: Manganese

Supports glucose and cholesterol metabolism

Limited

Essential for enzymes involved in carbohydrate, amino acid, and cholesterol metabolism, and may improve glucose tolerance in those with metabolic issues.

Particularly relevant for: People with metabolic syndrome · Individuals with poor diets

S4 · Am J Clin Nutr (2003): Manganese intake and glucose metabolism S7 · Linus Pauling Institute: Manganese

Safety & Information

Important safety information & known risks

For educational purposes only • not medical advice

Generally safe within recommended doses, but excessive long-term intake may cause neurological effects or worsen certain health conditions.

warning notices

Excess intake (especially >11 mg/day) may cause neurological symptoms similar to Parkinson's disease.
More serious side effects include tremor, motor disturbances, and cognitive changes with prolonged high exposure.
Manganese is cleared by the liver, and those with liver disease are at higher risk of toxicity.
Do not use in individuals with active liver disease due to increased risk of toxicity.
Avoid use in people with iron deficiency anemia unless directed by a clinician, as manganese competes with iron for absorption.
Monitor neurological status in those on long-term supplementation or with environmental manganese exposure, as excess may cause neurotoxicity.
Use only under medical supervision in pregnancy or with known neurodegenerative conditions.

Known interactions with medications

Levodopa/carbidopa: high manganese may reduce effectiveness in Parkinson’s disease.

Contraindications / special precautions

Active liver disease
Severe iron deficiency anemia
Known manganese toxicity

interactions

Important interactions between active ingredient ↔ supplement / medication / food

Manganese absorption or effectiveness may be influenced by other minerals, and excessive intake may increase risk when combined with certain drugs or conditions.