What is Zinc (Bisglycinate)?

Zinc (bisglycinate) is a chelated form of zinc bound to the amino acid glycine. Chelation can improve absorption and may be gentler on the stomach than some other zinc forms.

What are the main benefits of Zinc (Bisglycinate)?

It supports immune function, wound healing, and normal DNA synthesis and cell division. It also contributes to hormone and reproductive health and helps maintain normal taste and smell.

How much Zinc (Bisglycinate) should I take?

A common supplemental range is 15–30 mg of elemental zinc per day. Needs vary by diet and health status, and long-term high intake can increase the risk of copper deficiency.

When should I take Zinc (Bisglycinate) for best absorption?

It’s often taken with food to reduce nausea, though some people tolerate it well on an empty stomach. Zinc can compete with iron and calcium for absorption, so consider separating doses if taking those supplements.

Who should be cautious with Zinc (Bisglycinate)?

People who are pregnant or breastfeeding, have chronic medical conditions, or take medications should check with a clinician before supplementing. Avoid exceeding recommended amounts unless medically advised.

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Zinc
(Bisglycinate)

Strong study situation·10/10

A higher score indicates better study conditions, but not necessarily effectiveness.

Highly bioavailable chelated zinc; important for immunity, wound healing, and hormone health.

Tissue Repair Essential Nutrient Male Fertility Immune Booster Female Fertility

dose range

15–30 mg

Once daily or split between meals for tolerance.

Consumption

Take with food to reduce risk of stomach upset. Avoid taking with high-dose iron or calcium supplements unless directed by your healthcare provider.

Not fat-soluble.

Best time

Usually taken with the first or second meal of the day; food can enhance tolerance.

Description

Zinc bisglycinate is a chelated form of zinc bound to glycine, offering superior absorption compared to other forms. As a vital trace mineral, zinc supports immunity, DNA synthesis, and more.

benefits

Main effects with level of evidence

Strong

Note on evidence

Well-documented essential nutrient with strong evidence for benefits on immunity, wound healing, and deficiency correction.

Boosts Immune Function

Strong

Essential for development and function of immune cells, helping reduce infection duration and severity.

Particularly relevant for: general · immunity-compromised · athletes · elderly

2 · NIH

Supports Wound Healing

Strong

Promotes skin repair, tissue growth, and is especially important for healing after injury or surgery.

Particularly relevant for: general · post-surgery · athletes

2 · NIH

Ensures Healthy Growth and DNA Synthesis

Strong

Crucial for DNA synthesis, cell division, and normal development, especially during childhood and pregnancy.

Particularly relevant for: children · pregnant · general

2 · NIH

Promotes Hormone and Reproductive Health

Moderate

Needed for hormone production, sperm development, and reproductive health in both men and women.

Particularly relevant for: men · women · fertility-seekers

2 · NIH

Maintains Sense of Taste and Smell

Moderate

Zinc is required for normal function of taste and smell receptors; deficiency may cause loss or changes in these senses.

Particularly relevant for: elderly · general

2 · NIH

Safety & Information

Important safety information & known risks

For educational purposes only • not medical advice

Zinc bisglycinate is generally safe when used within recommended limits; excessive intake can cause adverse effects.

warning notices

Well-tolerated at standard doses; best with food to avoid nausea and GI upset.
Exceeding 40 mg daily long-term may risk copper deficiency and impair immune function.
Rarely, allergic reactions may occur.
Consult your doctor if pregnant, breastfeeding, or have chronic liver/kidney disease before use.

Known interactions with medications

Some antibiotics (e.g. tetracyclines, quinolones) – separate dosing to avoid absorption interference.
Penicillamine – zinc may reduce effectiveness; separate dosing.

Contraindications / special precautions

Copper deficiency
Severe kidney disease (unless medically indicated)

interactions

Important interactions between active ingredient ↔ supplement / medication / food

Zinc can interact with several nutrients and medications, affecting absorption and status.

Zinc can reduce copper absorption.

supplement · Copper

MonitorStrong

Why

High doses of zinc induce metallothionein, which binds copper and inhibits its absorption.

recommendation

Monitor copper status if taking high-dose zinc for extended periods. Consider supplementing with copper if required.

2 · NIH

Iron and zinc may compete for absorption.

supplement · Iron

SeparateModerateSeparate by 2h

Why

Both compete for absorption in the intestine, possibly reducing bioavailability when taken together in high doses.

recommendation

Take zinc and high-dose iron supplements at different times of day when possible (at least 2 hours apart).

2 · NIH

High doses of calcium may inhibit zinc absorption.

supplement · Calcium

SeparateLimitedSeparate by 2h

Why

Mineral competition in the gut can reduce zinc uptake when taken with large doses of calcium.

recommendation

Avoid taking high-dose calcium and zinc together.

2 · NIH

mechanisms of action

Brief explanations of how it works

Enhanced Bioavailability via Chelation

Zinc bisglycinate is chelated, meaning it is bound to glycine, improving gastrointestinal absorption compared to other zinc forms.

1 · PubMed

Cofactor for Over 300 Enzymes

Zinc acts as a cofactor for enzymes in immune function, DNA replication, protein synthesis, and antioxidant activity.

2 · NIH

Sources & References

Primary literature and reviews on which these statements are based

3 sources

PubMed

Study on the bioavailability of zinc bisglycinate.

NIH

Comprehensive overview of zinc benefits, safety, and dosage.

WebMD

General information on zinc, its uses, and cautions.

Laatst bijgewerkt: 13 maart 2026

This information is for educational purposes only and does not replace medical advice.