L-Citrulline
L-Citrulline is a non-essential amino acid supplement supporting cardiovascular health and exercise performance by increasing nitric oxide production.
L-Citrulline is an amino acid found in watermelon and produced in the human body. It plays a key role in the urea cycle and serves as a precursor to L-arginine and nitric oxide, influencing blood vessel function and athletic performance. Supplemental L-citrulline is widely used for cardiovascular support, exercise enhancement, and erectile function.
Most studies are small but consistent for cardiovascular and exercise benefits. Evidence for other health effects remains preliminary.
Supports Cardiovascular Health
ModerateSupplemental L-citrulline can help lower blood pressure and improve blood vessel function by boosting nitric oxide production, especially in people with prehypertension or hypertension.
Enhances Exercise Performance
ModerateL-citrulline supplementation may increase exercise capacity, reduce fatigue, and lessen muscle soreness after workouts, particularly in high-intensity or endurance activities.
May Improve Erectile Function
LimitedSupplementing with L-citrulline can moderately improve erectile hardness in men with mild to moderate erectile dysfunction by enhancing blood flow.
Supports Muscle Protein Synthesis
LimitedL-citrulline may help stimulate muscle protein synthesis, especially in older adults with low protein intake, aiding muscle maintenance.
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