L-Glycine
L-Glycine is a non-essential amino acid involved in neurotransmission, collagen synthesis, and metabolic regulation, with supplemental uses for sleep, mental health, and metabolic support.
L-Glycine is the simplest amino acid, produced by the body and found in high-protein foods. It is critical for collagen formation, helps regulate nerve impulses, and acts in multiple metabolic processes. Supplemental glycine is most studied for its effects on sleep, cognition, and as an adjunct in certain psychiatric and metabolic conditions.
Moderate evidence supports glycine for sleep improvement and adjunctive psychiatric therapy, with emerging but less robust evidence in metabolic and skin health applications.
Improved Sleep Quality
ModerateSupplemental glycine before bedtime improves sleep quality, reduces sleep latency, and enhances next-day cognitive performance, likely by lowering core body temperature and modulating neurotransmitter activity.
Adjunctive Treatment for Schizophrenia
ModerateWhen used alongside antipsychotic medications, glycine can modestly reduce negative symptoms in schizophrenia, likely by modulating NMDA receptor function.
Metabolic Regulation
LimitedGlycine supplementation may improve post-meal blood sugar control and insulin response, offering potential benefit in metabolic syndrome.
Collagen Synthesis and Skin Health
LimitedAs a major component of collagen, glycine supports skin health, wound healing, and tissue repair, though direct benefits from supplementation in healthy populations require further study.
Supporting Liver Health
LimitedGlycine may benefit liver function and protect against some forms of liver injury, based on preclinical and early human studies.
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