Vitamin B3
(Niacin)
Vitamin B3 (niacin) is an essential water-soluble vitamin critical for metabolism, skin, and nerve health, and is used at high doses for lipid management under medical supervision.
Vitamin B3, or niacin, includes nicotinic acid and niacinamide forms. It is vital for energy metabolism, DNA repair, and cellular health, and prevents the deficiency disease pellagra. While commonly obtained from diet, niacin’s high-dose form is sometimes used as a cholesterol-lowering agent under supervision.
Niacin’s essential role in metabolism and pellagra prevention is well established; pharmacological benefits for lipids are recognized but must be weighed against risk in high doses.
Prevents Pellagra
StrongAdequate niacin prevents pellagra, a potentially fatal deficiency disease marked by dermatitis, diarrhea, and dementia.
Supports Energy Metabolism
StrongNiacin is a precursor to NAD and NADP, coenzymes needed for hundreds of reactions in energy production and cellular repair.
Cholesterol Management (Prescription, High Dose)
ModerateNicotinic acid, when prescribed in high doses, can increase HDL cholesterol, lower LDL cholesterol, and decrease triglycerides, though use is limited by side effects and requires medical oversight.
Skin Health
ModerateNiacinamide (a form of B3) helps maintain the skin barrier, reduces inflammation, and may improve acne and rosacea.
Supports Nervous System and Cognitive Function
LimitedNiacin is essential for normal nervous system function; deficiency can cause neurological symptoms. Adequate intake supports cognitive health, though benefits of supplementation in non-deficient adults are less clear.
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