What is Celery Extract?

Celery extract is a concentrated preparation from Apium graveolens, commonly made from the seeds or stalks. It contains compounds such as phthalides, flavonoids, and polyphenols.

Can celery extract help with blood pressure?

Some clinical research suggests celery seed extract may support healthy blood pressure, possibly by promoting blood vessel relaxation. It should not replace prescribed blood pressure medication without medical guidance.

What is a typical dosage for celery extract?

Common supplemental amounts are often in the range of 75–150 mg per day, depending on the product and extract strength. Follow the label directions and consider discussing dosing with a clinician.

What are the possible side effects of celery extract?

Side effects can include digestive upset or allergic reactions, especially in people sensitive to celery. Stop use and seek medical advice if you develop symptoms of allergy.

Who should avoid celery extract or use caution?

People who are pregnant, have celery allergy, or take medications that affect blood pressure should use caution. Consult a healthcare professional before use if you have a medical condition or take regular medications.

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Celery Extract

Limited research available·3/10

A higher score indicates better study conditions, but not necessarily effectiveness.

Celery extract is a plant-based supplement used primarily for blood pressure, inflammation, and antioxidant support.

Anti-inflammatory Cardiovascular Support Joint Healt Antioxidant

dose range

75–150 mg

Twice daily

Consumption

Take with food to support absorption; begin with lower dose to assess tolerance.

Not fat-soluble.

Best time

Morning and/or any time; with meals is preferable.

Description

Celery extract (from Apium graveolens seeds or stalks) contains phthalides, flavonoids, and polyphenols. It is traditionally used for cardiovascular and anti-inflammatory benefits and is gaining popularity as a natural supplement for joint and heart health.

benefits

Main effects with level of evidence

Limited

Note on evidence

Preliminary clinical and animal studies suggest benefits for blood pressure and inflammation, but human evidence is limited and more research is needed.

Helps lower mild to moderate high blood pressure

Limited

Clinical studies indicate celery seed extract may help reduce systolic and diastolic blood pressure, likely due to phthalide compounds that promote blood vessel relaxation.

Particularly relevant for: Adults with mild hypertension

S1 · PubMed: Clinical study on blood pressure lowering effect of celery seed extract

May reduce inflammation and joint pain

Limited

Preclinical and early clinical studies suggest celery extract has anti-inflammatory effects, potentially reducing symptoms in conditions like osteoarthritis.

Particularly relevant for: Adults with arthritis or joint discomfort

S2 · PubMed: Anti-osteoarthritis effects of celery extract

Provides antioxidant support

Limited

Celery extract's polyphenols and flavonoids provide antioxidant protection, helping to neutralize free radicals and support overall cellular health.

Particularly relevant for: General population seeking oxidative stress protection

S3 · PubMed: Antioxidant activity of celery polyphenols

Safety & Information

Important safety information & known risks

For educational purposes only • not medical advice

Celery extract is generally safe but may cause allergic reactions and is not recommended during pregnancy or for people with kidney disorders.

warning notices

Allergic reactions, including skin rashes and anaphylaxis, have been reported in sensitive individuals.
Celery may affect blood clotting and increase bleeding risk when combined with anticoagulant drugs.
Not recommended during pregnancy due to possible uterine stimulation.
People with known kidney disorders should avoid celery extract.
Avoid use if you are allergic to celery or related plants.
Do not use during pregnancy due to possible uterine stimulation.
Use caution and consult a healthcare professional if taking anticoagulant medications (e.g., warfarin).
Avoid use with known kidney disorders unless under medical supervision.

Known interactions with medications

Warfarin and other anticoagulants
Diuretics

Contraindications / special precautions

Pregnancy
Celery allergy
Kidney disorders

interactions

Important interactions between active ingredient ↔ supplement / medication / food

Celery extract may interact with blood thinners and diuretic medications, potentially altering effects or increasing side effect risk.

Celery extract may increase bleeding risk when combined with anticoagulants.

drug · Warfarin

CautionLimited

Why

Celery may contain compounds that affect blood clotting and interact with drugs like warfarin, increasing bleeding risk.

recommendation

Consult a health professional before use; monitor for signs of bleeding.

S4 · WebMD: Celery S7 · Drugs.com: Celery extract professional information

Celery extract may enhance the effect of diuretics and contribute to low potassium.

drug · Diuretics

CautionTheoretical

Why

Celery has mild diuretic properties that could add to drug-induced fluid or electrolyte loss.

recommendation

Monitor electrolyte levels with long-term or high-dose combined use.

S6 · Examine.com: Celery seed S7 · Drugs.com: Celery extract professional information

mechanisms of action

Brief explanations of how it works

Phthalide-mediated vasodilation

Phthalides in celery extract promote relaxation of vascular smooth muscle, leading to improved blood flow and lower blood pressure.

S1 · PubMed: Clinical study on blood pressure lowering effect of celery seed extract

Inhibition of pro-inflammatory cytokines

Celery extract suppresses inflammatory mediators such as TNF-α and IL-1β, which may reduce arthritis and joint inflammation.

S2 · PubMed: Anti-osteoarthritis effects of celery extract

Antioxidant enzyme activation

Celery polyphenols stimulate antioxidant enzyme activity, protecting cells from oxidative stress.

S3 · PubMed: Antioxidant activity of celery polyphenols

Sources & References

Primary literature and reviews on which these statements are based

8 sources

PubMed: Clinical study on blood pressure lowering effect of celery seed extract

PubMed: Anti-osteoarthritis effects of celery extract

PubMed: Antioxidant activity of celery polyphenols

WebMD: Celery

NIH National Center for Complementary and Integrative Health (NCCIH): Celery Seed

Examine.com: Celery seed

Drugs.com: Celery extract professional information

MedlinePlus: Celery

Last updated: February 8, 2026

This information is for educational purposes only and does not replace medical advice.