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Pine Extract
(Pycnogenol)

Moderate study situation·7/10
A higher score indicates better study conditions, but not necessarily effectiveness.

Pine Extract (Pycnogenol) is a standardized maritime pine bark extract used for cardiovascular, antioxidant, and skin support.

Anti-inflammatoryCardiovascular SupportCognitive EnhancementAntioxidantSkin Health
dose range
100–200 mg
one or two divided doses daily
Consumption
Take with or without food; splitting the dose may improve tolerance in sensitive individuals.
Not fat-soluble.
Best time
Morning or first meal preferred for convenience.

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Description

Pycnogenol, derived from French maritime pine bark (Pinus pinaster), is rich in proanthocyanidins and bioflavonoids, used as a supplement for cardiovascular and skin health due to its potent antioxidant and anti-inflammatory properties.

benefits
Main effects with level of evidence
Moderate
Note on evidence

Numerous clinical trials support cardiovascular and skin health benefits, with moderate evidence for antioxidant and anti-inflammatory effects.

Supports cardiovascular and vascular health

Moderate

Pycnogenol has been shown to improve endothelial function, lower blood pressure, and alleviate symptoms in chronic venous insufficiency and related vascular conditions.

Particularly relevant for: adults with mild hypertension · individuals with chronic venous insufficiency · general adult population
S3 · Rohdewald P. (2002) Pycnogenol® French maritime pine bark extract. Review of clinical applications.S4 · Belcaro G, et al. (2013) Pycnogenol for the management of chronic venous insufficiency, edema, and other vascular conditions.S7 · Cesarone MR, et al. (2012) Pycnogenol supplementation and blood pressure.S8 · Packer L, et al. (1999) Pycnogenol in prevention of cardiovascular disease.

Provides antioxidant and anti-inflammatory protection

Moderate

Acts as a potent antioxidant, helping to neutralize free radicals and lower oxidative stress, and has demonstrated reductions in markers of inflammation in clinical studies.

Particularly relevant for: adults with oxidative stress · people with chronic inflammatory conditions
S3 · Rohdewald P. (2002) Pycnogenol® French maritime pine bark extract. Review of clinical applications.S6 · Examine.com: Pycnogenol

Improves skin hydration and elasticity

Moderate

Supplementation increases skin hydration, elasticity, and smoothness, and may reduce UV-induced skin damage in women.

Particularly relevant for: adults seeking skin anti-aging support
S5 · Saliou C, et al. (2001) Antioxidant and skin health effects of Pycnogenol in women.

May support cognitive function and attention

Limited

Some studies suggest potential improvements in cognitive performance and attention, particularly in aging populations, though evidence is limited.

Particularly relevant for: older adults
S6 · Examine.com: Pycnogenol

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This information is for educational purposes only and does not replace medical advice.
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This website is for educational and informational purposes only and does not constitute medical advice or professional services. The information provided should not be used to diagnose or treat any health problem or disease. Persons requiring medical advice should consult a licensed physician.