What are the potential benefits of Cat’s Claw?

Limited human evidence suggests it may support certain immune responses and may help with inflammatory symptoms such as joint pain in some people. Overall clinical evidence is modest.

What is a typical dosage for Cat’s Claw?

Common supplemental amounts are around 300–500 mg per day, depending on the product and extract. Follow the label directions and consult a clinician if you have medical conditions.

What are the side effects and safety concerns?

Side effects can include gastrointestinal upset and other intolerance reactions. People who are pregnant or breastfeeding, have autoimmune conditions, or take immunosuppressants or blood thinners should seek medical advice before use.

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Cat's Claw
(Uncaria tomentosa)

Limited research available·3/10

A higher score indicates better study conditions, but not necessarily effectiveness.

Traditional Amazonian vine supplement with limited evidence for immune and anti-inflammatory support.

Digestion & Gut Health Anti-inflammatory Joint Healt Antioxidant Immune Booster

dose range

300–500 mg

Divided into 2–3 doses with food.

Consumption

Take with meals to minimize gastrointestinal side effects.

Not fat-soluble.

Best time

Usually taken in the morning or with meals; do not exceed six months without medical supervision.

Description

Cat’s Claw (Uncaria tomentosa) is an Amazon rainforest vine used in traditional medicine. It contains alkaloids and other phytochemicals believed to have anti-inflammatory and immune-modulating effects, but clinical evidence is modest and safety caution is warranted.

benefits

Main effects with level of evidence

Limited

Note on evidence

Small clinical trials suggest some benefit for osteoarthritis and immune function, but robust evidence from large-scale studies is lacking.

May support immune function

Limited

Limited studies suggest Cat’s Claw can stimulate certain immune responses, possibly improving resistance to infections.

Particularly relevant for: General Population · Immune Support Seekers

s1 · Healthline: Cat’s Claw Benefits, Dosage, and Side Effects s2 · Mount Sinai: Cat’s Claw s3 · NCCIH: Cat's Claw

Potential anti-inflammatory effects

Limited

Some evidence from small randomized controlled trials indicates Cat’s Claw may help reduce pain and swelling in osteoarthritis or rheumatoid arthritis.

Particularly relevant for: Adults with inflammatory joint conditions

s2 · Mount Sinai: Cat’s Claw s5 · Examine.com: Cat’s Claw s7 · EMA Assessment Report: Uncaria tomentosa

Mild antioxidant properties

Limited

Contains compounds that may neutralize free radicals and contribute to cellular protection, but clinical impact is unclear.

Particularly relevant for: General Population

s1 · Healthline: Cat’s Claw Benefits, Dosage, and Side Effects s3 · NCCIH: Cat's Claw s5 · Examine.com: Cat’s Claw

Safety & Information

Important safety information & known risks

For educational purposes only • not medical advice

Likely safe for short-term use at recommended dosages, but carries risks for certain populations.

warning notices

GI upset (nausea, diarrhea) is possible.
May lower blood pressure significantly in sensitive individuals.
Potential to worsen autoimmune conditions.
Avoid in pregnancy, breastfeeding, kidney disease, or before surgery.
Avoid use if pregnant or breastfeeding.
Do not use if you have an autoimmune disease.
Use with caution or avoid if you have a bleeding disorder or are scheduled for surgery.
Avoid use if you have kidney disease or Parkinson’s disease.
Monitor for hypotension if using blood pressure medications.
Use only with clinician supervision if taking immunosuppressive drugs.

Known interactions with medications