What is grape vine leaf extract?

Grape vine leaf extract is made from the leaves of Vitis vinifera. It contains polyphenols and flavonoids that provide antioxidant and anti-inflammatory activity.

What is grape vine leaf extract used for?

It is commonly used to support symptoms of chronic venous insufficiency (CVI), such as leg heaviness, pain, and swelling. It may also be used for general vascular support.

Does grape vine leaf extract help with leg swelling?

It may help reduce leg edema, including ankle or calf swelling, particularly when related to venous issues such as varicose veins or prolonged standing.

What is a typical dosage for grape vine leaf extract?

Common supplemental amounts are in the range of 360–720 mg per day. Follow the product label and consult a clinician if you have medical conditions or take medications.

Who should be cautious with grape vine leaf extract?

People who are pregnant or breastfeeding, have bleeding disorders, or take anticoagulant or antiplatelet medications should consult a healthcare professional before use. Stop use and seek advice if you develop unusual bleeding or allergic reactions.

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Grape Vine
Leaf Extract

Moderate study situation·7/10

A higher score indicates better study conditions, but not necessarily effectiveness.

Extract of Vitis vinifera leaves, used for chronic venous insufficiency and vascular support due to its antioxidant and anti-inflammatory properties.

Longevity Anti-inflammatory Cardiovascular Support Antioxidant

dose range

360–720 mg

Divided into 2 doses per day, often morning and with later meal

Consumption

Take with meals to enhance absorption and reduce GI discomfort.

Not fat-soluble.

Best time

Bioavailability is improved with food; take at roughly the same time each day for consistency.

Description

Grape vine leaf extract is derived from Vitis vinifera and traditionally used to treat symptoms of chronic venous insufficiency (CVI) like leg pain, heaviness, and swelling. It is rich in polyphenols and flavonoids, conferring antioxidant and anti-inflammatory effects that may benefit cardiovascular and vascular health.

benefits

Main effects with level of evidence

Moderate

Note on evidence

Clinical trials support its effectiveness in CVI; antioxidant benefits are mechanistically supported and studied in animals and in vitro.

Alleviates symptoms of chronic venous insufficiency (CVI)

Moderate

Reduces leg pain, swelling, and heaviness in individuals with CVI by improving venous tone and decreasing capillary permeability.

Particularly relevant for: Adults with mild-to-moderate CVI · Individuals with venous leg symptoms

1 · PubMed: Red vine leaf extract in chronic venous insufficiency 2 · PubMed: Clinical efficacy of red vine leaf extract in CVI

Reduces leg swelling and edema

Moderate

Helps decrease calf and ankle swelling in people with leg edema, particularly in those with varicose veins or who stand for prolonged periods.

Particularly relevant for: Individuals with leg edema or varicose veins

2 · PubMed: Clinical efficacy of red vine leaf extract in CVI

Provides antioxidant and anti-inflammatory support

Limited

Supplying flavonoids and polyphenols, it helps neutralize free radicals and reduce inflammation, potentially supporting cardiovascular and general health.

Particularly relevant for: People seeking antioxidant support

3 · PubMed: Antioxidant activity of grape vine leaf 5 · Examine.com: Red vine leaf extract

Safety & Information

Important safety information & known risks

For educational purposes only • not medical advice

Generally well tolerated in studied doses, but monitoring is advised for at-risk populations.

warning notices

Avoid use in individuals allergic to grapes or grape-derived products.
Do not use in pregnancy or lactation due to limited safety data.
Monitor for possible bleeding if taking anticoagulant medications.
Avoid if allergic to grapes or grape-derived products.
Do not use during pregnancy or breastfeeding due to insufficient safety data.
Use only with clinician supervision if taking anticoagulant or antiplatelet medications (possible increased bleeding risk).

Known interactions with medications

May increase the effect of anticoagulants or antiplatelet drugs.

Contraindications / special precautions

Pregnancy
Breastfeeding
Known grape allergy

interactions

Important interactions between active ingredient ↔ supplement / medication / food

Potential interactions with anticoagulant and antiplatelet drugs due to possible increased bleeding risk.

May increase bleeding risk when combined with blood thinners.

drug · anticoagulants

CautionLimited

Why

Grape vine leaf extract may have mild antiplatelet or blood-thinning properties that can augment effects of anticoagulation therapy.

recommendation

Monitor for bleeding symptoms and use under medical supervision if on blood thinners.

4 · WebMD: Grape vine leaf 6 · NIH NCCIH: Grape seed extract and related products 7 · Drugs.com: Vitis vinifera (Grape Leaf) Monograph

mechanisms of action

Brief explanations of how it works

Reduces capillary permeability and improves venous tone

Flavonoids in grape vine leaf stabilize capillary walls and enhance venous return, contributing to reduced swelling and pain in CVI.

1 · PubMed: Red vine leaf extract in chronic venous insufficiency 2 · PubMed: Clinical efficacy of red vine leaf extract in CVI

Antioxidant scavenging of free radicals

Polyphenols and flavonoids (e.g., quercetin, resveratrol) in the extract neutralize free radicals and may protect vascular endothelium.

3 · PubMed: Antioxidant activity of grape vine leaf 5 · Examine.com: Red vine leaf extract

Sources & References

Primary literature and reviews on which these statements are based

8 sources

PubMed: Red vine leaf extract in chronic venous insufficiency

PubMed: Clinical efficacy of red vine leaf extract in CVI

PubMed: Antioxidant activity of grape vine leaf

WebMD: Grape vine leaf

Examine.com: Red vine leaf extract

NIH NCCIH: Grape seed extract and related products

Covers safety and interactions of grape derivatives.

Drugs.com: Vitis vinifera (Grape Leaf) Monograph

EFSA Journal: Safety and efficacy of grape vine leaf extracts

Laatst bijgewerkt: 7 februari 2026

This information is for educational purposes only and does not replace medical advice.