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Trans-
Resveratrol

Moderate study situation·7/10
A higher score indicates better study conditions, but not necessarily effectiveness.

Trans-Resveratrol is a polyphenolic antioxidant found in grapes and berries, researched for its cardiovascular, anti-inflammatory, and neuroprotective effects.

LongevityAnti-AgingAnti-inflammatoryCardiovascular SupportCognitive EnhancementAntioxidantNeuroprotective
dose range
150–500 mg
1-2 doses daily with meals
Consumption
Take with food, ideally split between first and second meals to enhance absorption.
Fat-soluble: take with fat.
Best time
Taking with fat-containing meals or piperine may improve absorption.

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Description

Trans-Resveratrol is the bioactive isomer of resveratrol, a natural compound present in grape skins, red wine, berries, and peanuts. It is widely studied for potential healthspan, vascular, and brain benefits, though its oral bioavailability is low.

benefits
Main effects with level of evidence
Moderate
Note on evidence

Human studies suggest beneficial effects, though many findings remain preliminary or require further replication.

Supports Cardiovascular Health

Moderate

May improve endothelial function, reduce blood pressure, and decrease LDL cholesterol oxidation, contributing to a reduced risk of cardiovascular disease.

Particularly relevant for: Adults with cardiovascular risk · General Adults
S1 · NIH: Resveratrol Fact Sheet (ODS)S3 · PubMed: “Clinical evidence of resveratrol benefits”S6 · Examine.com: Resveratrol SummaryS7 · Cochrane Review: Resveratrol for cardiovascular health

Anti-Inflammatory and Antioxidant Effects

Moderate

Acts as a potent antioxidant and anti-inflammatory agent, reducing levels of C-reactive protein and oxidative stress markers.

Particularly relevant for: Adults with chronic inflammation · General Adults
S1 · NIH: Resveratrol Fact Sheet (ODS)S2 · PubMed Review: “Safety and Efficacy of Resveratrol in Human Subjects”S6 · Examine.com: Resveratrol Summary

Neuroprotective Effects

Limited

May activate sirtuins and protect neural tissue, with potential to slow cognitive decline and protect against neurodegenerative diseases; some evidence in animal models and emerging data in humans.

Particularly relevant for: Older adults · At-risk for neurodegeneration
S4 · PubMed: “The neuroprotective effects of resveratrol”S1 · NIH: Resveratrol Fact Sheet (ODS)

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This information is for educational purposes only and does not replace medical advice.
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This website is for educational and informational purposes only and does not constitute medical advice or professional services. The information provided should not be used to diagnose or treat any health problem or disease. Persons requiring medical advice should consult a licensed physician.