What is persimmon extract?

Persimmon extract is a concentrated preparation made from the fruit of Diospyros kaki. It contains antioxidants such as polyphenols and carotenoids, along with vitamins and minerals.

What are the potential benefits of persimmon extract?

It is commonly used for antioxidant support and is being studied for cardiometabolic health, including cholesterol and blood pressure support. Evidence varies by product and study type, and human data are still limited for some uses.

How much persimmon extract should I take?

Common supplemental amounts are about 250–500 mg per day, depending on the extract and its concentration. Follow the product label and consider discussing dosing with a clinician if you have medical conditions.

Is persimmon extract safe?

It is generally well tolerated when used as directed, but side effects can include digestive upset in some people. Use caution if you are pregnant or breastfeeding, have chronic conditions, or take medications, and consult a healthcare professional.

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Persimmon
Extract

Limited research available·3/10

A higher score indicates better study conditions, but not necessarily effectiveness.

Persimmon extract is a plant-derived supplement rich in antioxidants and nutrients, studied for heart and metabolic health benefits.

Eye Health Cardiovascular Support Essential Nutrient Antioxidant Cholesterol Management Weight Management

dose range

250–500 mg

Once daily or split into two doses with meals.

Consumption

Take with food for best absorption and gastrointestinal tolerance.

Not fat-soluble.

Best time

Typically taken with the first or second meal.

Description

Persimmon extract comes from Diospyros kaki fruit, native to East Asia and valued for its vitamin, mineral, and phytochemical content. It is popular in health supplements for its antioxidant profile and potential cardiometabolic benefits.

benefits

Main effects with level of evidence

Limited

Note on evidence

Most evidence comes from animal studies and small human trials; robust clinical evidence is limited.

Supports Eye Health

Limited

Contains carotenoids such as beta-carotene and lutein that may contribute to eye health and protection against oxidative stress.

Particularly relevant for: Aging adults · People with high screen-time

S1 · Healthline - Persimmon Nutrition and Benefits S5 · Nutritional Composition and Health Effects of Persimmon (Molecules, 2022)

May Support Heart Health

Limited

Compounds in persimmon extract, including polyphenols and fiber, may help lower blood pressure and cholesterol according to preliminary studies.

Particularly relevant for: Adults at risk for cardiovascular disease

S3 · Atsuhiro I, et al. (2020) – Effects of persimmon intake on cholesterol and oxidative markers (PubMed)S5 · Nutritional Composition and Health Effects of Persimmon (Molecules, 2022)

Antioxidant Properties

Limited

Rich in vitamin C and polyphenols, persimmon extract may reduce oxidative stress by neutralizing free radicals.

Particularly relevant for: General population

S1 · Healthline - Persimmon Nutrition and Benefits S4 · NIH National Center for Complementary and Integrative Health - Antioxidants S5 · Nutritional Composition and Health Effects of Persimmon (Molecules, 2022)

Potential Contribution to Weight Management

Limited

Early studies suggest persimmon extract may influence lipid metabolism, but conclusive evidence in humans is lacking.

Particularly relevant for: Adults aiming for weight management

S5 · Nutritional Composition and Health Effects of Persimmon (Molecules, 2022)

Provides Essential Nutrients

Limited

Persimmon extract supplies vitamins A, C, K, E, and minerals such as potassium, supporting general health.

Particularly relevant for: General population

S1 · Healthline - Persimmon Nutrition and Benefits S2 · WebMD - Japanese Persimmon Information S5 · Nutritional Composition and Health Effects of Persimmon (Molecules, 2022)

Safety & Information

Important safety information & known risks

For educational purposes only • not medical advice

Generally safe when used orally and appropriately. Adverse effects are rare and mostly associated with excessive intake.

warning notices

High doses may cause digestive discomfort, such as diarrhea or mild gastrointestinal upset.
Natural sugar content may impact blood glucose; caution advised for diabetics.
Very rare allergic reactions reported in those sensitive to persimmon fruit.
Monitor intake if diabetic or using glucose-lowering medication.
Avoid use if allergic to persimmon or related fruits.

Known interactions with medications

Use with caution alongside antidiabetic or antihypertensive drugs due to possible additive effects.

Contraindications / special precautions

Confirmed persimmon allergy.
Individuals with uncontrolled diabetes should avoid unsupervised use.

interactions

Important interactions between active ingredient ↔ supplement / medication / food

Persimmon extract may modestly influence blood sugar and blood pressure. Monitor for interactions with antidiabetic and antihypertensive drugs.

May potentiate the effects of antidiabetic drugs.

drug · Antidiabetic medication

MonitorLimited

Why

Persimmon extract may mildly lower blood sugar, increasing risk of hypoglycemia when combined with blood glucose-lowering medications.

recommendation

Monitor blood sugar closely and consult a healthcare provider if symptoms of hypoglycemia occur.

S2 · WebMD - Japanese Persimmon Information

May enhance blood pressure-lowering effect.

drug · Antihypertensive medication

MonitorLimited

Why

Some preliminary research suggests persimmon extract could mildly lower blood pressure; combined use with antihypertensive drugs may require monitoring.

recommendation

Monitor blood pressure for additive effects.

S3 · Atsuhiro I, et al. (2020) – Effects of persimmon intake on cholesterol and oxidative markers (PubMed)

mechanisms of action

Brief explanations of how it works