What is Fadogia Agrestis Extract?

Fadogia Agrestis Extract comes from the West African shrub Fadogia agrestis. It is commonly marketed for male sexual health and purported testosterone support.

Does Fadogia Agrestis Extract increase testosterone in humans?

There is little to no direct human evidence that it increases testosterone. Most support for this claim comes from animal studies, which may not translate to people.

What are the potential benefits of Fadogia Agrestis Extract?

Animal studies suggest possible effects on testosterone-related markers and sexual behavior, and some report analgesic or anti-inflammatory activity. Human relevance and real-world benefits remain uncertain.

What is a typical dosage range for Fadogia Agrestis Extract?

Common supplemental amounts are often listed around 100–600 mg per day. Optimal dosing is not established due to limited human research.

Is Fadogia Agrestis Extract safe?

Safety in humans is not well established, and product quality can vary between brands. People with medical conditions, those taking medications, or those who are pregnant or breastfeeding should consult a clinician before use.

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Fadogia Agrestis
Extract

Limited research available·3/10

A higher score indicates better study conditions, but not necessarily effectiveness.

Extract from the Fadogia agrestis shrub, traditionally used for male sexual health and purported testosterone support, but lacking human evidence.

Testosterone Booster Anti-inflammatory Male Fertility Hormone Balance

dose range

100–600 mg

Once daily, in the morning or pre-workout

Consumption

Orally, with or without food.

Not fat-soluble.

Best time

Safety of split vs. single dose not established; consider morning or pre-workout to align with theoretical energy benefits.

Description

Fadogia agrestis is a West African shrub whose extracts are marketed as testosterone boosters and aphrodisiacs. Most claims are based on animal studies, with little to no direct human evidence.

benefits

Main effects with level of evidence

Limited

Note on evidence

Most evidence is restricted to animal and in vitro studies. No quality human RCTs or pharmacokinetic data are available.

Possible Testosterone Support (Animal Data Only)

Limited

Animal studies suggest that Fadogia agrestis may increase serum testosterone, likely via stimulation of luteinizing hormone, but these effects are unproven in humans.

Particularly relevant for: Men seeking hormone support

1 · PubMed – Asian Journal of Andrology 5 · Examine.com

Traditional Aphrodisiac Effects (Animal Data Only)

Limited

Fadogia agrestis has demonstrated increased sexual activity and libido in male rats, echoing its folkloric use as an aphrodisiac; relevance to humans is unknown.

Particularly relevant for: Men seeking sexual performance improvement

2 · PubMed – International Journal of Impotence Research 5 · Examine.com6 · NIH National Center for Complementary and Integrative Health (NCCIH)

Animal Evidence for Analgesic and Anti-Inflammatory Activity

Limited

Some animal studies report reduced pain and inflammation with Fadogia agrestis extracts, potentially due to modulation of inflammatory mediators.

Particularly relevant for: Individuals interested in herbal pain relief

3 · PubMed – Journal of Ethnopharmacology 5 · Examine.com

Safety & Information

Important safety information & known risks

For educational purposes only • not medical advice

Long-term human safety is unknown. Animal toxicity is reported at high doses; liver and kidney function risks require caution.

warning notices

Potential for liver and kidney toxicity observed in animal studies at high dosages.
Not recommended for pregnant or breastfeeding women.
No established human safety data for prolonged use or high doses.
Avoid use in pregnancy or breastfeeding due to insufficient safety data.
Do not use if you have pre-existing liver or kidney disease due to potential toxicity observed in animal studies.
Monitor liver and kidney function during use, particularly if used for more than a few weeks.
Avoid or use only with clinician supervision if using hormone-related medications due to unestablished endocrine effects.

Known interactions with medications

Hormonal agents (testosterone, SERMs, anti-androgens)
Drugs with liver/kidney toxicity risk

Contraindications / special precautions

Pregnancy
Breastfeeding
Liver disease
Kidney disease

interactions

Important interactions between active ingredient ↔ supplement / medication / food

Clinically relevant nutrient or drug interactions are unproven, but theoretical interactions exist based on hormonal activity and animal toxicity data.

May increase risk of liver toxicity with hepatotoxic medications.

drug · Hepatotoxic drugs

AvoidLimited

Why

Animal studies show increased liver enzyme levels at high doses; possible cumulative liver stress with other drugs affecting liver.

recommendation

Avoid concurrent use with medications known to carry liver toxicity risk.

3 · PubMed – Journal of Ethnopharmacology 4 · WebMD

Risk of nephrotoxicity may be increased with other nephrotoxic agents.

drug · Nephrotoxic drugs

AvoidLimited

Why

Animal studies suggest kidney enzyme elevations at high doses, potentially compounding risk with other nephrotoxic substances.

recommendation

Do not use with other medications or supplements causing kidney stress unless directed by a physician.

3 · PubMed – Journal of Ethnopharmacology 4 · WebMD

Potential unpredictable interactions with hormone therapy.

drug · Hormone therapies (testosterone, SERMs, anti-androgens)

CautionTheoretical

Why

Animal studies indicate changes in testosterone and luteinizing hormone; unclear effects in humans may impact treatments involving sex hormones.

recommendation

Consult a healthcare provider before combining with hormone therapies.

1 · PubMed – Asian Journal of Andrology 5 · Examine.com

mechanisms of action

Brief explanations of how it works

Possible Modulation of Gonadal Hormones

Fadogia agrestis may stimulate luteinizing hormone, increasing testosterone in animal models, but human relevance is unknown.

1 · PubMed – Asian Journal of Andrology 5 · Examine.com

Potential Analgesic/Anti-Inflammatory Activity

Animal data suggest inhibition of inflammatory mediators, possibly explaining observed pain-relieving effects.

3 · PubMed – Journal of Ethnopharmacology

Sources & References

Primary literature and reviews on which these statements are based

7 sources

PubMed – Asian Journal of Andrology

Animal study on testosterone increases

PubMed – International Journal of Impotence Research

Animal study on aphrodisiac effects

PubMed – Journal of Ethnopharmacology

Analgesic effects – animal data

WebMD

General overview, safety

Examine.com

Research summary, safety, efficacy

NIH National Center for Complementary and Integrative Health (NCCIH)

Context for traditional use of herbal aphrodisiacs

US Dietary Supplement Label Database

Product composition reference

Laatst bijgewerkt: 7 maart 2026

This information is for educational purposes only and does not replace medical advice.

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164 items

Fadogia AgrestisExtract

Description

benefits

Possible Testosterone Support (Animal Data Only)

Traditional Aphrodisiac Effects (Animal Data Only)

Animal Evidence for Analgesic and Anti-Inflammatory Activity

Safety & Information

interactions

May increase risk of liver toxicity with hepatotoxic medications.

Risk of nephrotoxicity may be increased with other nephrotoxic agents.

Potential unpredictable interactions with hormone therapy.

mechanisms of action

Possible Modulation of Gonadal Hormones

Potential Analgesic/Anti-Inflammatory Activity

Sources & References

Botanicals & Natural Substances

Andere categorieën

Safety & Information

interactions

May increase risk of liver toxicity with hepatotoxic medications.

Risk of nephrotoxicity may be increased with other nephrotoxic agents.

Potential unpredictable interactions with hormone therapy.

mechanisms of action

Possible Modulation of Gonadal Hormones

Potential Analgesic/Anti-Inflammatory Activity

Sources & References

Fadogia Agrestis
Extract