Fisetin is a naturally occurring flavonoid found in small amounts in foods such as strawberries and apples. It is also sold as a dietary supplement for cellular health and healthy aging.

What are the potential benefits of fisetin?

Preclinical research suggests fisetin may have senolytic, antioxidant, and anti-inflammatory effects and may support brain health. Most evidence is from cell, animal, and disease-model studies, with human research still limited.

What is a typical fisetin dose?

Supplement doses commonly fall around 100–200 mg per day, depending on the product and goal. Follow label directions and consult a clinician for personalized guidance.

Is fisetin safe and are there side effects?

Fisetin is generally well tolerated in many supplement users, but side effects can include digestive upset or other individual reactions. Safety data in pregnancy, breastfeeding, and certain medical conditions are limited.

Can fisetin interact with medications?

It may interact with some medications or supplements, especially those affecting blood clotting or inflammation pathways. If you take prescription drugs or have a chronic condition, check with a healthcare professional before use.

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Fisetin

Limited research available·3/10

A higher score indicates better study conditions, but not necessarily effectiveness.

Naturally occurring flavonoid with senolytic, antioxidant, and anti-inflammatory potential, under study for longevity and brain health.

Longevity Anti-Aging Anti-inflammatory Cognitive Enhancement Antioxidant Neuroprotective

dose range

100–200 mg

Once daily, or intermittently at higher doses for senolytic protocols.

Consumption

Take with food to improve absorption. Liposomal or fat-based formulations may further enhance bioavailability.

Not fat-soluble.

Best time

Most studies suggest taking in the morning or with the first meal.

Description

Fisetin is a plant-derived flavonoid found in small amounts in fruits and vegetables like strawberries and apples. It is marketed as a supplement for cellular health, anti-aging, and cognitive support, with most evidence still coming from preclinical and animal studies.

benefits

Main effects with level of evidence

Limited

Note on evidence

While preclinical data on fisetin are strong, especially for senolytic and neuroprotective effects, robust human data are limited to pilot studies and case reports.

Senolytic and anti-aging effects

Limited

Shown to reduce senescent cells and markers of aging in animal models and increase lifespan in mice. Human studies are ongoing.

Particularly relevant for: Longevity · Anti-Aging

2 · Yousefzadeh MJ et al., Nature Medicine 2018 5 · Maher P, Free Radic Biol Med 2018 7 · ClinicalTrials.gov – Fisetin

Neuroprotective effects

Limited

Improves cognitive performance, reduces neuroinflammation, and may offer support in Alzheimer’s models (preclinical evidence).

Particularly relevant for: Cognitive Enhancement · Neuroprotective

3 · Currais A et al., Aging Cell 2017 5 · Maher P, Free Radic Biol Med 2018

Antioxidant and anti-inflammatory action

Limited

Reduces oxidative stress and inflammation by modulating pro-inflammatory pathways (mostly animal/in vitro data).

Particularly relevant for: Anti-inflammatory · Antioxidant

4 · Singh M et al., Phytotherapy Research 2018 5 · Maher P, Free Radic Biol Med 2018

Safety & Information

Important safety information & known risks

For educational purposes only • not medical advice

Appears well tolerated at typical doses, but safety in humans is not fully established.

warning notices

GI discomfort and mild symptoms at high doses reported anecdotally.
Not recommended for use in pregnancy, breastfeeding, or in individuals on anticoagulants/with bleeding disorders due to insufficient data.
Avoid if pregnant or breastfeeding due to insufficient safety data.
Use only under clinician supervision if taking anticoagulant or antiplatelet medication, as fisetin may increase bleeding risk.
Individuals with bleeding disorders should avoid fisetin supplementation.

Known interactions with medications

Anticoagulants (warfarin, apixaban, etc.)

Contraindications / special precautions

Pregnancy
Breastfeeding
Bleeding disorders
Concomitant use of anticoagulant medication

interactions

Important interactions between active ingredient ↔ supplement / medication / food

Limited human data exist, but fisetin may interact with drugs affecting blood clotting.

May increase bleeding risk with anticoagulant drugs.

drug · Anticoagulants (e.g., warfarin, apixaban)

CautionLimited

Why

Fisetin may inhibit platelet aggregation and affect blood coagulation.

recommendation

Monitor for signs of increased bleeding and consult a healthcare provider before combining.

1 · WebMD6 · NIH Office of Dietary Supplements – Fisetin Fact Sheet

mechanisms of action

Brief explanations of how it works

Senolytic activity

Selective elimination of senescent cells via apoptosis induction improves tissue function in preclinical models.

2 · Yousefzadeh MJ et al., Nature Medicine 2018 5 · Maher P, Free Radic Biol Med 2018

Inhibition of pro-inflammatory pathways

Modulates NF-κB and reduces expression of inflammatory cytokines.

4 · Singh M et al., Phytotherapy Research 2018 5 · Maher P, Free Radic Biol Med 2018

Antioxidant activity

Scavenges free radicals and increases antioxidant enzyme expression.

4 · Singh M et al., Phytotherapy Research 2018 5 · Maher P, Free Radic Biol Med 2018

Sources & References

Primary literature and reviews on which these statements are based

7 sources

WebMD

Yousefzadeh MJ et al., Nature Medicine 2018

Seminal study on senolytic properties.

Currais A et al., Aging Cell 2017

Neuroprotective effects in Alzheimer's models.

Singh M et al., Phytotherapy Research 2018

Review on anti-inflammatory and antioxidant effects.

Maher P, Free Radic Biol Med 2018

Overview of human and animal studies.

NIH Office of Dietary Supplements – Fisetin Fact Sheet

Fact sheet for general overview.

ClinicalTrials.gov – Fisetin

Database of human clinical trials.

Laatst bijgewerkt: 13 februari 2026

This information is for educational purposes only and does not replace medical advice.

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Fisetin

Description

benefits

Senolytic and anti-aging effects

Neuroprotective effects

Antioxidant and anti-inflammatory action

Safety & Information

interactions

May increase bleeding risk with anticoagulant drugs.

mechanisms of action

Senolytic activity

Inhibition of pro-inflammatory pathways

Antioxidant activity

Sources & References

Botanicals & Natural Substances

Andere categorieën

Safety & Information

interactions

May increase bleeding risk with anticoagulant drugs.

mechanisms of action

Senolytic activity

Inhibition of pro-inflammatory pathways

Antioxidant activity

Sources & References