Rutin is a plant polyphenolic flavonoid (bioflavonoid) found in foods such as buckwheat, apples, and tea. It is used for antioxidant and vascular-support purposes.

What are the main benefits of rutin?

Rutin is commonly used to support vascular and capillary health, provide antioxidant protection, and help modulate inflammation. Effects can vary by person and condition.

How much rutin should I take?

Common supplemental amounts are around 500–1000 mg per day. Follow the product label and consult a clinician if you have medical conditions or take medications.

Is rutin safe, and who should be cautious?

Rutin is generally well tolerated for many people, but side effects can occur. People who are pregnant or breastfeeding, have bleeding disorders, or use blood-thinning or antiplatelet medications should consult a healthcare professional before use.

313 wetenschappelijk onderbouwde voedingsstoffen

3251 bronnen geraadpleegd

Informatie ingedeeld naar bewijs

Verken op doel of categorie

Voedingsstof vinden

Populaire keuzes

Eicosapentaenoic acid (EPA)Vitamin D3 Docosahexaenoic acid (DHA)Zinc (Bisglycinate)

313 voedingsstoffen totaal

Vitamin B

Vitamin B1 (Thiamine)

Vitamin B2 (Riboflavin)

Vitamin B3 (Niacin)

Vitamin B5 (Pantothenic Acid)

Vitamin B6 (Pyridoxine)

Vitamin B7 (Biotin)

Vitamin B9 (Folic Acid)

Vitamin B12 (Methylcobalamin)

Vitamin B12 (Cobalamin)

Vitamin A & Carotenoids

Vitamin C

Vitamin D

Vitamin E

Vitamin K

Vitaminoids

Trimethylglycine (Betaine)

NMN (Nicotinamide Mononucleotide)

Pyrroloquinoline Quinone (PQQ)

D-Chiro-Inositol

Coenzym Q10 (Ubiquinone)

Betaine HCL

Nicotinamide Riboside

Vitamin B8 (Myo-Inositol)

Choline

Citicoline (CDP-Choline)

Coenzyme Q10 (Ubiquinol)

Calcium

Calcium Alpha-Ketoglutarate

Magnesium

Magnesium Bisglycinate

Magnesium L-Threonate

Trace Minerals

Copper (Bisglycinate)

Chromium Picolinate

Manganese (Bisglycinate)

Zinc

Pentadecanoic Acid (C15:0)

Phosphatidylserine

R-Alpha Lipoic Acid

Black Cumin Oil

Extra Virgin Olive Oil

Ceratiq wheat oil extract

Phospholipids

Algae Oil

Fish Oil

Conjugated Linoleic Acid

Gamma-Aminobutyric Acid

Alpha-Linolenic Acid

Gamma-Linolenic Acid

Omega-3

Docosapentaenoic acid (DPA)

Eicosapentaenoic acid (EPA)

Docosahexaenoic acid (DHA)

AminoMar

Acetyl-L-Carnitine

PABA (para-aminobenzoic acid)

Essential Amino Acids

Conditionally Essential Amino Acids

L-Theanine

Non-Essential Amino Acids

Beta-Alanine

L-Cysteine Hydrochloride

Amino Acid Derivative

Taurine

Creatine (Hydrochloride)

L-Arginine Alpha-Ketoglutarate

Creatine (Monohydrate)

Akkermansia muciniphila

Lactobacillus Reuteri

Probiotics

Bifidobacterium longum BB536

Prebiotics

Stinging Nettle Extract

Pomegranate Polyphenols

Red Beet Extract

Pine Extract (Pycnogenol)

Oligomeric Proanthocyanidins (OPC)

Ashwagandha Root Extract

Methylsulfonylmethane (MSM)

Citrus Sinensis Extract

Horsetail Stem Extract

Flax Seed Extract

Sulforaphane Glucosinolate

Garlic Extract

Black Pepper

Apricot Kernel Extract

Lovage

Spiny Rest Harrow Root Extract

Juniper Berry Extract

Bearberry Leaf Extract

White Kidney Bean Extract

Lady’s Mantle Extract

Bitter Orange Extract

St. John’s Wort Extract

Japanese Knotweed Extract

Hydroxytyrosol/tyrosol

Olive extract

Sesame seed lignan extract

Broccoli Sprout Extract

Cranberry Extract

Flavon Glycosides

Gentian Root Extract

Griffonia simplicifolia Extract

Ajuga Turkestanica Extract

Amaranthus Leaf Extract

Banaba Extract

Boswellia Extract

Capsaicin

Cayenne Pepper Extract

Celery Extract

Ceylon Cinnamon Extract

Chamomile Extract

Charantin

Chinese Goldthread Root Extract

Citrus Aurantium Extract

Cocoa Extract

Cyanotis Arachnoidea Extract

Fadogia Agrestis Extract

Garcinia Cambogia Extract

Goldenrod Extract

Green Tea Extract

Guarana Extract

Horse Chestnut Extract

Grapefruit Seed Extract

Grape Vine Leaf Extract

Green Tea Polyphenols

Epigallocatechin Gallate (EGCG)

Adaptogens

Cordyceps sinensis extract

Ginsenoside

Lion's Mane (Hericium erinaceus)

Ginseng Extract

Cat's Claw (Uncaria tomentosa)

Arjuna (Terminalia arjuna)

Tribulus Terrestris Extract

Rhodiola rosea

Panax Ginseng Extract

Mushrooms

Reishi Extract

Astragalus Polysaccharides

Hyaluronic Acid

Glucosamine Sulfate

Chondroitin Sulfate

Glucosamine Sulphate 2KCL

Rutin

Moderate study situation·7/10

A higher score indicates better study conditions, but not necessarily effectiveness.

A plant bioflavonoid supporting vascular health, antioxidant protection, and inflammation reduction.

Anti-inflammatory Cardiovascular Support Antioxidant

dose range

500–1000 mg

Divided in 2 doses daily.

Consumption

Take with meals to enhance absorption and minimize GI discomfort; often paired with vitamin C for potential synergistic benefits.

Not fat-soluble.

Best time

Split dosing with breakfast and dinner is common.

Description

Rutin is a polyphenolic flavonoid found in foods like buckwheat, apples, and tea. It is commonly supplemented for vascular health and its antioxidant properties.

benefits

Main effects with level of evidence

Moderate

Note on evidence

Human and animal research supports vascular and antioxidant effects, but larger trials are limited.

Supports vascular health

Moderate

Rutin helps strengthen blood vessels and capillaries, potentially reducing symptoms of chronic venous insufficiency, varicose veins, and hemorrhoids.

Particularly relevant for: Adults with vascular concerns

S1 · Angiology S7 · Phytotherapy Research

Antioxidant action

Moderate

Acts as a potent antioxidant, neutralizing free radicals and reducing oxidative stress, which may lower risk of chronic conditions.

Particularly relevant for: Adults seeking antioxidant support

S3 · International Journal of Molecular Sciences S2 · NIH Office of Dietary Supplements S4 · Examine.com S8 · Journal of Clinical Biochemistry and Nutrition

Anti-inflammatory effects

Moderate

Reduces activity of inflammatory enzymes and mediators, supporting joint and tissue health, and may reduce inflammatory discomfort.

Particularly relevant for: Adults with inflammatory conditions

S3 · International Journal of Molecular Sciences S8 · Journal of Clinical Biochemistry and Nutrition

Safety & Information

Important safety information & known risks

For educational purposes only • not medical advice

Generally well-tolerated, but caution is needed for high-risk groups and drug interactions.

warning notices

Rare side effects include mild headache, flushing, or GI upset.
Not recommended during pregnancy or breastfeeding due to lack of safety data.
Potential increase in bleeding risk when combined with anticoagulant drugs.
Avoid during pregnancy or breastfeeding due to insufficient safety data.
Avoid use with anticoagulant or antiplatelet medications due to potential increased bleeding risk.
Monitor for allergic reactions especially in individuals sensitive to flavonoids.

Known interactions with medications