What is Amaranthus Leaf Extract?

Amaranthus Leaf Extract is a supplement made from the leaves of Amaranthus plants. It contains bioactive compounds such as phenolics and flavonoids found in amaranth leaves.

What are the main potential benefits of Amaranthus Leaf Extract?

It is commonly used for antioxidant and anti-inflammatory support. It may also provide nutritional support and has preliminary evidence for helping support healthy blood sugar metabolism.

What is a typical dosage for Amaranthus Leaf Extract?

Common supplemental amounts are about 200–500 mg per day. Follow the product label and consider medical advice if you have health conditions or take medications.

Can Amaranthus Leaf Extract help with blood sugar control?

Some preclinical research suggests it may help support blood glucose regulation and affect carbohydrate-digesting enzymes. Human evidence is limited, so it should not replace prescribed diabetes care.

Is Amaranthus Leaf Extract safe for everyone?

Many people tolerate plant extracts well, but reactions can vary. Use caution if pregnant or breastfeeding, if you have allergies, or if you take blood sugar-lowering medicines.

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Amaranthus Leaf
Extract

Moderate study situation·7/10

A higher score indicates better study conditions, but not necessarily effectiveness.

Amaranthus leaf extract is a plant-derived supplement valued for its antioxidant, anti-inflammatory, and potential blood sugar-regulating properties.

Anti-inflammatory Essential Nutrient Antioxidant Immune Booster Bone Health Glucose Metabolism

dose range

200–500 mg

Divided into two daily doses with meals.

Consumption

Take with food to support absorption of both water- and any fat-soluble compounds present.

Not fat-soluble.

Best time

Best taken with meals, typically in the morning and/or with the first meal of the day.

Description

Amaranthus leaf extract comes from the leaves of the Amaranthus plant, used traditionally as a nutritious vegetable and now studied for its bioactive compounds in supplemental form.

benefits

Main effects with level of evidence

Moderate

Note on evidence

Evidence is mostly from cell and animal models, with limited human studies; notable antioxidant and anti-inflammatory effects are supported by early research.

Antioxidant activity

Moderate

Rich in phenolic compounds and flavonoids, Amaranthus leaf extract can scavenge free radicals and may help lower oxidative stress.

Particularly relevant for: Adults seeking antioxidant support

1 · Journal of Food Science and Technology

Anti-inflammatory effects

Moderate

Bioactive constituents may reduce pro-inflammatory cytokines and help modulate inflammatory pathways, potentially supporting inflammatory balance.

Particularly relevant for: Those with inflammatory conditions

2 · International Journal of Molecular Sciences

Nutritional support and immune benefits

Limited

Contains significant amounts of vitamins A, C, and minerals which support immune function and overall nutrient intake.

Particularly relevant for: Individuals needing nutritional support

4 · NIH Review: Nutritional value and safety aspects of Amaranthus sp.

Potential blood sugar regulation

Limited

Animal studies indicate Amaranthus leaf extract may assist in lowering blood glucose and inhibiting carbohydrate-digesting enzymes.

Particularly relevant for: Those at risk for elevated blood sugar

3 · Pharmaceutical Biology

Bone health support

Theoretical

Provides minerals such as calcium, which are important for bone maintenance.

Particularly relevant for: People at risk of osteoporosis

4 · NIH Review: Nutritional value and safety aspects of Amaranthus sp.

Safety & Information

Important safety information & known risks

For educational purposes only • not medical advice

Generally safe for most healthy adults at typical supplemental doses; certain groups should exercise extra caution.

warning notices

Possible mild gastrointestinal discomfort or allergic reactions in sensitive individuals.
Avoid during pregnancy due to lack of safety data.
Consult a healthcare provider if you have kidney disorders or a history of kidney stones due to oxalate content.
May affect blood sugar if combined with antidiabetic drugs.
Avoid use during pregnancy due to insufficient safety data.
Consult a healthcare provider before use in kidney disease due to high oxalate content.
Monitor blood sugar closely if using antidiabetic medications.

Known interactions with medications

Antidiabetic medications

Contraindications / special precautions

Pregnancy
Kidney disease

interactions

Important interactions between active ingredient ↔ supplement / medication / food

Interactions are mainly theoretical, relating to potential hypoglycemic effects and oxalate renal burden.

May enhance effects of antidiabetic medications

drug · antidiabetic medications

MonitorLimited

Why

Amaranthus leaf extract may lower blood sugar; combining with diabetes drugs can increase hypoglycemia risk.

recommendation

Monitor blood sugar levels regularly and adjust diabetes medications if necessary.

3 · Pharmaceutical Biology

Contains high dietary oxalate, may interact with calcium absorption

nutrient · Calcium

CautionTheoreticalCalcium

Why

Oxalate may bind to calcium, potentially reducing calcium absorption.

recommendation

If using for calcium supplementation or if at risk for kidney stones, take calcium at a different time.

4 · NIH Review: Nutritional value and safety aspects of Amaranthus sp.

mechanisms of action

Brief explanations of how it works

Free radical scavenging

Antioxidant polyphenols neutralize reactive oxygen species and may reduce oxidative cellular damage.

1 · Journal of Food Science and Technology

Anti-inflammatory pathway modulation

Bioactive compounds downregulate inflammatory mediators including cytokines as shown in cell models.

2 · International Journal of Molecular Sciences

Alpha-glucosidase inhibition

May inhibit carbohydrate-digesting enzymes, leading to decreased glucose absorption and lower post-meal blood sugar in animal models.

3 · Pharmaceutical Biology

Mineral nutritional support

Provides essential minerals (iron, calcium) important for metabolic and bone health.

4 · NIH Review: Nutritional value and safety aspects of Amaranthus sp.

Sources & References

Primary literature and reviews on which these statements are based

4 sources

Journal of Food Science and Technology

Covers antioxidant properties of Amaranthus leaf extract.

International Journal of Molecular Sciences

Details anti-inflammatory effects of Amaranthus leaves.

Pharmaceutical Biology

Evaluates antidiabetic activity in rat models.

NIH Review: Nutritional value and safety aspects of Amaranthus sp.

Comprehensive assessment of safety and nutrition.

Laatst bijgewerkt: 8 februari 2026

This information is for educational purposes only and does not replace medical advice.