What is verbascoside (acteoside)?

Verbascoside, also called acteoside, is a phenylethanoid glycoside found in various plants such as Lemon Verbena. It is studied mainly for antioxidant and anti-inflammatory activity.

What are the potential benefits of verbascoside?

Preclinical research suggests antioxidant, anti-inflammatory, neuroprotective, antimicrobial, and skin-supporting effects. Strong conclusions in humans are limited due to a lack of robust clinical trials.

Is there an established human dosage for verbascoside?

No established evidence-based human dosage is available. Amounts in supplements vary by extract and standardization, so follow product labeling and consult a clinician if unsure.

Is verbascoside safe?

Human safety data is limited, and effects may depend on the source extract and dose. People who are pregnant or breastfeeding, have medical conditions, or take medications should consult a healthcare professional before use.

Where is verbascoside found?

It occurs naturally in several plants and is commonly associated with Lemon Verbena and other polyphenol-rich botanicals. It may be present in certain herbal extracts and supplements.

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Verbascoside

Limited research available·3/10

A higher score indicates better study conditions, but not necessarily effectiveness.

Verbascoside is a plant-derived antioxidant and anti-inflammatory compound under research for multiple health benefits, but lacks established human dosing.

Anti-inflammatory Cardiovascular Support Cancer-inhibitor Antioxidant Neuroprotective

dose range

0–0

Consumption

Usually consumed as part of plant extract in tea or supplements. No specific human dosing established.

Not fat-soluble.

Best time

If used, take with meals to promote tolerance.

Description

Verbascoside (also called acteoside) is a phenylethanoid glycoside found in plants like Lemon Verbena, prized for its antioxidant and anti-inflammatory properties. Most evidence comes from animal or in vitro studies; robust human clinical data is limited.

benefits

Main effects with level of evidence

Limited

Note on evidence

Most research on verbascoside is preclinical (animal/cell studies). Human studies are rare, so benefits are theoretical or extrapolated.

Antioxidant Activity

Limited

Verbascoside helps neutralize free radicals and reduces oxidative stress, which may contribute to disease prevention.

Particularly relevant for: People seeking antioxidant support

S1 · PubMed–Phenylethanoid Glycosides: Chemistry and Biological Activity S3 · Nutrients–Biological Activities and Pharmacological Properties of Verbascoside: Recent Findings and Perspectives (2023)

Anti-inflammatory Effects

Limited

Verbascoside inhibits inflammatory mediators and shows promise in reducing inflammation, which may support cardiovascular and joint health.

Particularly relevant for: Individuals with inflammation-related conditions

S2 · Verbascoside: Insight into Its Promising Pharmacological Activities, Mechanisms of Action, and Potential Clinical Applications. Inflammopharmacology (2024)S3 · Nutrients–Biological Activities and Pharmacological Properties of Verbascoside: Recent Findings and Perspectives (2023)

Neuroprotective Properties

Limited

Preclinical studies suggest verbascoside protects neurons from oxidative stress and may support brain health or neurodegenerative conditions.

Particularly relevant for: People interested in brain health · Aging populations

S2 · Verbascoside: Insight into Its Promising Pharmacological Activities, Mechanisms of Action, and Potential Clinical Applications. Inflammopharmacology (2024)S5 · Frontiers in Pharmacology–Potential Therapeutic Roles of Verbascoside in Neuroprotection

Antimicrobial Activity

Limited

Verbascoside has shown inhibitory effects on various bacteria and fungi in laboratory studies, but significance in humans is unknown.

Particularly relevant for: General adult population

S3 · Nutrients–Biological Activities and Pharmacological Properties of Verbascoside: Recent Findings and Perspectives (2023)

Skin and Wound Healing Support

Limited

Verbascoside may promote skin healing and reduce inflammation, based on in vitro and animal research.

Particularly relevant for: Individuals interested in skin health

Safety & Information

Important safety information & known risks

For educational purposes only • not medical advice

Human safety data is limited; most studies use plant extracts with no significant adverse effects at typical dietary levels.

warning notices

No significant adverse events reported in human studies with food amounts.
High-dose or concentrated forms not well studied for safety.
Do not use Verbascoside supplements if pregnant or breastfeeding due to lack of safety data.
Avoid high-dose verbascoside without medical supervision as effects are not well studied in humans.
Individuals with known hypersensitivity to plants containing verbascoside should avoid use.

Contraindications / special precautions