Silybin
Primary active component of milk thistle silymarin, silybin is a flavonolignan best known for liver protection and antioxidant effects.
Silybin (silibinin) is the major bioactive compound in silymarin, the extract of milk thistle seeds. It is widely used for liver health, antioxidant support, and as an adjunct in certain clinical situations, though limited by its oral bioavailability.
Clinical studies support benefits for liver health, while most anti-inflammatory and anti-cancer findings are preliminary or preclinical.
Protects and supports liver health
ModerateSilybin supports liver cell membrane stability, enhances regeneration, and protects the liver from toxins, alcohol, and certain drugs. It is used adjunctively in chronic liver diseases and may improve markers such as ALT, AST, and histological outcomes.
Antioxidant activity
ModerateActs as a free radical scavenger and supports cellular antioxidant defense, reducing markers of oxidative stress, particularly in metabolic conditions.
Anti-inflammatory effects
LimitedPreclinical and some clinical evidence suggests silybin may lower inflammation by inhibiting pro-inflammatory cytokines, potentially benefiting metabolic and inflammatory diseases.
Emerging anti-cancer adjunct
LimitedPreclinical and limited clinical studies indicate potential in inhibiting tumor cell growth and enhancing effects of conventional cancer therapies.
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