What is sulforaphane glucosinolate?

Sulforaphane glucosinolate is a plant compound found in cruciferous vegetables, especially broccoli sprouts. It can be converted into sulforaphane, an isothiocyanate associated with cellular defense pathways.

How does sulforaphane glucosinolate work in the body?

When converted to sulforaphane, it can activate the Nrf2 pathway, which helps regulate antioxidant and detoxification enzymes. It may also influence inflammatory signaling.

What foods are high in sulforaphane glucosinolate?

Broccoli sprouts are among the richest sources, with broccoli, Brussels sprouts, kale, and other Brassica vegetables also providing related glucosinolates. Preparation and chewing can affect conversion to sulforaphane.

What is a typical dosage range for sulforaphane glucosinolate?

Common supplemental ranges are often listed around 20–100 mg per day, depending on the product and its conversion to sulforaphane. Follow label directions and consider discussing use with a clinician, especially if pregnant, breastfeeding, or managing a medical condition.

Bilimsel destekli 313 besin

3251 kaynak incelendi

Kanıta dayalı bilgiler

Hedefe veya kategoriye göre keşfet

Sulforaphane
Glucosinolate

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Daha yüksek puan, daha iyi bir çalışma durumuna işaret eder, ancak mutlaka etkinlik anlamına gelmez.

A potent isothiocyanate from cruciferous vegetables, sulforaphane supports antioxidant defenses, anti-inflammatory processes, and cellular protection.

Anti-inflammatory Cardiovascular Support Cancer-inhibitor Antioxidant Neuroprotective

Doz aralığı

20–100 mg

Taken as a single dose or split with meals.

Gelir

Consume with meals to support absorption. Ensure supplement includes active myrosinase or co-consume with myrosinase-rich foods for optimal conversion.

Yağda çözünmez.

En iyi zaman

Morning or first meal is preferred; avoid taking on an empty stomach if GI sensitivity occurs.

Açıklama

Sulforaphane glucosinolate is a natural plant compound concentrated in broccoli sprouts and other Brassica vegetables. Activated during digestion, it has gained attention for its cellular protective, anti-inflammatory, and possible anticancer effects, though human trials remain limited.

Avantajlar

Kanıt derecesi ile ana etkiler

Moderate

Kanıtla ilgili not

Several preclinical and small human studies show antioxidative and anti-inflammatory effects; chemopreventive potential is promising but not definitive in humans.

Cellular Antioxidant Support

Moderate

Activates Nrf2 pathway, boosting production of detoxification and antioxidant enzymes.

Özellikle ilgili olduğu kişiler: General population · Older adults · Individuals at risk of oxidative stress

S1 · PubMed Review: The role of sulforaphane in human health S2 · NIH: Sulforaphane—Review Article

Anti-Inflammatory Effects

Moderate

Reduces markers of inflammation, including C-reactive protein, and modulates pathways associated with chronic inflammatory conditions.

Özellikle ilgili olduğu kişiler: Individuals with inflammatory conditions · Cardiovascular risk groups

S2 · NIH: Sulforaphane—Review Article S3 · Examine.com: Sulforaphane Evidence Summary

Chemoprotective/Anticancer Properties

Limited

May inhibit cancer cell growth and induce apoptosis; evidence strongest in preclinical models and some human observational studies.

Özellikle ilgili olduğu kişiler: Individuals with higher cancer risk

S2 · NIH: Sulforaphane—Review Article S6 · Linus Pauling Institute, Oregon State University—Micronutrient Information Center: Sulforaphane

Neuroprotection

Limited

May reduce oxidative damage in the brain and support cognitive health, with preliminary support from animal and early human studies.

Özellikle ilgili olduğu kişiler: Older adults · Neurodegenerative risk

S1 · PubMed Review: The role of sulforaphane in human health S4 · EFSA Scientific Opinion on Glucosinolates in Brassica vegetables

Güvenlik ve Uyarılar

Önemli güvenlik bilgileri ve bilinen riskler

Sadece eğitim amaçlıdır • tıbbi tavsiye değildir

Generally well-tolerated, but may cause mild gastrointestinal effects and has cautions in specific populations.

Uyarılar

High doses may cause nausea, bloating, or mild GI upset.
Potential goitrogenic effects, especially in those with low iodine or thyroid conditions.
Limited data on safety for pregnant or breastfeeding women.
Avoid use if you have known thyroid disorders, as sulforaphane may act as a goitrogen.
Use only under medical supervision if pregnant or breastfeeding due to limited safety data.
Monitor for drug interactions if you take medications affected by liver enzymes (CYP450).

İlaçlarla bilinen etkileşimler

CYP450 substrates

Kontrendikasyonlar / özel dikkat gerektiren gruplar

Thyroid disorders
Pregnancy or breastfeeding (unless approved by clinician)

etkileşimler

Etkin madde ↔ takviye / ilaç / gıda arasındaki önemli etkileşimler

Interactions primarily relate to effects on thyroid health and drug metabolism.

Sulforaphane may interfere with iodine uptake.

nutrient · Iodine

MonitorModerate

Neden

As a goitrogen, it can reduce thyroid hormone production, especially if iodine intake is low.

Öneri

Monitor thyroid function and ensure adequate iodine intake if consuming sulforaphane regularly, especially with known thyroid disorders.

S4 · EFSA Scientific Opinion on Glucosinolates in Brassica vegetables

Sulforaphane may impact the metabolism of drugs processed by CYP450 enzymes.

drug · CYP450 substrates

MonitorLimited

Neden

It can induce or inhibit certain CYP450 enzymes, altering blood levels of medications.

Öneri

Consult your healthcare provider if you are taking medications metabolized by the liver, such as warfarin, antiepileptics, or statins.

S1 · PubMed Review: The role of sulforaphane in human health S3 · Examine.com: Sulforaphane Evidence Summary

Etki mekanizmaları

Nasıl çalıştığına dair kısa açıklamalar

Nrf2 Pathway Activation

Sulforaphane activates nuclear factor erythroid 2–related factor 2 (Nrf2), leading to upregulation of antioxidant and cytoprotective enzymes.

S1 · PubMed Review: The role of sulforaphane in human health S2 · NIH: Sulforaphane—Review Article

Inflammatory Pathway Modulation (NF-κB)

Inhibits NF-κB signaling, reducing pro-inflammatory cytokine expression.

S2 · NIH: Sulforaphane—Review Article S3 · Examine.com: Sulforaphane Evidence Summary

Epigenetic Modulation

May influence histone deacetylase (HDAC) activity, impacting gene expression and cellular health.

S6 · Linus Pauling Institute, Oregon State University—Micronutrient Information Center: Sulforaphane

Kaynaklar ve Referanslar

Bu ifadelerin dayandığı birincil kaynaklar ve incelemeler

6 sources

PubMed Review: The role of sulforaphane in human health

NIH: Sulforaphane—Review Article

Examine.com: Sulforaphane Evidence Summary

EFSA Scientific Opinion on Glucosinolates in Brassica vegetables

WebMD: Sulforaphane Supplement Overview

Linus Pauling Institute, Oregon State University—Micronutrient Information Center: Sulforaphane

Son güncelleme: 13 Şubat 2026

Bu bilgiler yalnızca bilgilendirme amaçlıdır ve tıbbi tavsiye yerine geçmez.

Tüm besinler

Botanicals & Natural Substances

164 kayıt

SulforaphaneGlucosinolate

Açıklama

Avantajlar

Cellular Antioxidant Support

Anti-Inflammatory Effects

Chemoprotective/Anticancer Properties

Neuroprotection

Güvenlik ve Uyarılar

etkileşimler

Sulforaphane may interfere with iodine uptake.

Sulforaphane may impact the metabolism of drugs processed by CYP450 enzymes.

Etki mekanizmaları

Nrf2 Pathway Activation

Inflammatory Pathway Modulation (NF-κB)

Epigenetic Modulation

Kaynaklar ve Referanslar

Botanicals & Natural Substances

Diğer kategoriler

Güvenlik ve Uyarılar

etkileşimler

Sulforaphane may interfere with iodine uptake.

Sulforaphane may impact the metabolism of drugs processed by CYP450 enzymes.

Etki mekanizmaları

Nrf2 Pathway Activation

Inflammatory Pathway Modulation (NF-κB)

Epigenetic Modulation

Kaynaklar ve Referanslar

Sulforaphane
Glucosinolate