Apigenin is a natural plant flavonoid found in foods such as parsley, celery, and chamomile. It is also available as a dietary supplement.

What are the potential benefits of apigenin?

Apigenin is studied for antioxidant and anti-inflammatory effects and for supporting relaxation and sleep. Experimental research also explores anticancer activity, but human clinical evidence is limited.

How much apigenin should I take?

Common supplemental amounts are about 50–100 mg per day. Individual needs vary, so consider starting low and consult a clinician if you have medical conditions.

Does apigenin help with anxiety or sleep?

Apigenin may promote relaxation through effects on GABA-related pathways, and chamomile extracts containing apigenin have been studied for mild anxiety and sleep support. Results can vary between individuals.

Is apigenin safe and are there interactions?

Apigenin from foods is generally well tolerated, while supplement safety depends on dose and individual factors. If you are pregnant, breastfeeding, or taking medications, consult a healthcare professional due to potential interactions.

Bilimsel destekli 313 besin

3251 kaynak incelendi

Kanıta dayalı bilgiler

Hedefe veya kategoriye göre keşfet

Besin bul

Popüler seçimler

Eicosapentaenoic acid (EPA)Vitamin D3 Docosahexaenoic acid (DHA)Zinc (Bisglycinate)

Toplam 313 besin

Vitamin B

Vitamin B1 (Thiamine)

Vitamin B2 (Riboflavin)

Vitamin B3 (Niacin)

Vitamin B5 (Pantothenic Acid)

Vitamin B6 (Pyridoxine)

Vitamin B7 (Biotin)

Vitamin B9 (Folic Acid)

Vitamin B12 (Methylcobalamin)

Vitamin B12 (Cobalamin)

Vitamin A & Carotenoids

Vitamin C

Vitamin D

Vitamin E

Vitamin K

Vitaminoids

Trimethylglycine (Betaine)

NMN (Nicotinamide Mononucleotide)

Pyrroloquinoline Quinone (PQQ)

D-Chiro-Inositol

Coenzym Q10 (Ubiquinone)

Betaine HCL

Nicotinamide Riboside

Vitamin B8 (Myo-Inositol)

Choline

Citicoline (CDP-Choline)

Coenzyme Q10 (Ubiquinol)

Calcium

Calcium Alpha-Ketoglutarate

Magnesium

Magnesium Bisglycinate

Magnesium L-Threonate

Trace Minerals

Copper (Bisglycinate)

Chromium Picolinate

Manganese (Bisglycinate)

Zinc

Pentadecanoic Acid (C15:0)

Phosphatidylserine

R-Alpha Lipoic Acid

Black Cumin Oil

Extra Virgin Olive Oil

Ceratiq wheat oil extract

Phospholipids

Algae Oil

Fish Oil

Conjugated Linoleic Acid

Gamma-Aminobutyric Acid

Alpha-Linolenic Acid

Gamma-Linolenic Acid

Omega-3

Docosapentaenoic acid (DPA)

Eicosapentaenoic acid (EPA)

Docosahexaenoic acid (DHA)

AminoMar

Acetyl-L-Carnitine

PABA (para-aminobenzoic acid)

Essential Amino Acids

Conditionally Essential Amino Acids

L-Theanine

Non-Essential Amino Acids

Beta-Alanine

L-Cysteine Hydrochloride

Amino Acid Derivative

Taurine

Creatine (Hydrochloride)

L-Arginine Alpha-Ketoglutarate

Creatine (Monohydrate)

Akkermansia muciniphila

Lactobacillus Reuteri

Probiotics

Bifidobacterium longum BB536

Prebiotics

Stinging Nettle Extract

Pomegranate Polyphenols

Red Beet Extract

Pine Extract (Pycnogenol)

Oligomeric Proanthocyanidins (OPC)

Ashwagandha Root Extract

Methylsulfonylmethane (MSM)

Citrus Sinensis Extract

Horsetail Stem Extract

Flax Seed Extract

Sulforaphane Glucosinolate

Garlic Extract

Black Pepper

Apricot Kernel Extract

Lovage

Spiny Rest Harrow Root Extract

Juniper Berry Extract

Bearberry Leaf Extract

White Kidney Bean Extract

Lady’s Mantle Extract

Bitter Orange Extract

St. John’s Wort Extract

Japanese Knotweed Extract

Hydroxytyrosol/tyrosol

Olive extract

Sesame seed lignan extract

Broccoli Sprout Extract

Cranberry Extract

Flavon Glycosides

Gentian Root Extract

Griffonia simplicifolia Extract

Ajuga Turkestanica Extract

Amaranthus Leaf Extract

Banaba Extract

Boswellia Extract

Capsaicin

Cayenne Pepper Extract

Celery Extract

Ceylon Cinnamon Extract

Chamomile Extract

Charantin

Chinese Goldthread Root Extract

Citrus Aurantium Extract

Cocoa Extract

Cyanotis Arachnoidea Extract

Fadogia Agrestis Extract

Garcinia Cambogia Extract

Goldenrod Extract

Green Tea Extract

Guarana Extract

Horse Chestnut Extract

Grapefruit Seed Extract

Grape Vine Leaf Extract

Green Tea Polyphenols

Epigallocatechin Gallate (EGCG)

Adaptogens

Cordyceps sinensis extract

Ginsenoside

Lion's Mane (Hericium erinaceus)

Ginseng Extract

Cat's Claw (Uncaria tomentosa)

Arjuna (Terminalia arjuna)

Tribulus Terrestris Extract

Rhodiola rosea

Panax Ginseng Extract

Mushrooms

Reishi Extract

Astragalus Polysaccharides

Hyaluronic Acid

Glucosamine Sulfate

Chondroitin Sulfate

Glucosamine Sulphate 2KCL

Apigenin

Sınırlı araştırma durumu·3/10

Daha yüksek puan, daha iyi bir çalışma durumuna işaret eder, ancak mutlaka etkinlik anlamına gelmez.

Apigenin is a natural plant flavonoid studied for its antioxidant, anti-inflammatory, calming, and anticancer properties.

Longevity Sleep Improvement Anti-inflammatory Cancer-inhibitor Stress Relief Antioxidant Anxiety Relief

Doz aralığı

50–100 mg

Taken once daily, preferably in the evening.

Gelir

Take with a small meal or as directed by a healthcare professional. Consuming with food may aid absorption.

Yağda çözünmez.

En iyi zaman

Often taken in the evening or before sleep to leverage calming effects.

Açıklama

Apigenin is a flavonoid found in foods like parsley, celery, and chamomile. It is available as a supplement, most commonly used to reduce inflammation, relieve mild anxiety, and promote relaxation or sleep.

Avantajlar

Kanıt derecesi ile ana etkiler

Limited

Kanıtla ilgili not

Preclinical and early human studies suggest potential for inflammation and anxiety support, but robust clinical evidence is limited.

May reduce inflammation

Limited

Preclinical studies and limited human evidence suggest apigenin can reduce biomarkers of inflammation, possibly aiding inflammatory conditions.

Özellikle ilgili olduğu kişiler: Adults seeking anti-inflammatory support

S2 · PubMed – Anti-inflammatory activity of apigenin S8 · International Journal of Molecular Sciences – Apigenin and inflammation

May relieve mild anxiety and aid sleep

Limited

Evidence from clinical trials in chamomile extract and animal studies indicates apigenin may reduce mild anxiety and promote relaxation or sleep, likely via GABAergic pathways.

Özellikle ilgili olduğu kişiler: Adults with mild anxiety or sleep disturbances

S3 · PubMed – Apigenin for anxiety: Chamomile extract clinical trial S5 · Examine.com – Apigenin

Experimental anticancer activity

Theoretical

Laboratory and animal studies show apigenin may inhibit the growth and spread of various cancer cells, mainly by inducing apoptosis and modulating cell signaling; human clinical data is lacking.

Özellikle ilgili olduğu kişiler: Individuals interested in cancer prevention (experimental)

S4 · Cancer Letters – Anticancer mechanisms of apigenin S5 · Examine.com – Apigenin

Antioxidant support

Limited

Acts as an antioxidant, scavenging free radicals and supporting cellular health; primary evidence is from preclinical studies.

Özellikle ilgili olduğu kişiler: Adults seeking antioxidant support

S1 · NIH Office of Dietary Supplements – Flavonoids Fact Sheet S6 · Molecules – Bioavailability and food sources of apigenin

Güvenlik ve Uyarılar

Önemli güvenlik bilgileri ve bilinen riskler

Sadece eğitim amaçlıdır • tıbbi tavsiye değildir

Generally well-tolerated at typical doses, but caution is advised in sensitive groups and when combined with certain medications.

Uyarılar

Adverse effects are rare but can include allergic reactions and increased drowsiness if combined with sedatives.
Long-term safety has not been established, especially at high doses.
Avoid use during pregnancy and breastfeeding due to insufficient safety data.
Consult a healthcare provider before use if taking sedatives, anticoagulants, or antiplatelet drugs due to potential interactions.
Avoid if allergic to chamomile or related plants (Asteraceae/Compositae family).

İlaçlarla bilinen etkileşimler

sedatives
anticoagulants
antiplatelet drugs

Kontrendikasyonlar / özel dikkat gerektiren gruplar

Pregnancy
Breastfeeding
Allergy to chamomile or related plants

etkileşimler

Etkin madde ↔ takviye / ilaç / gıda arasındaki önemli etkileşimler

Apigenin may interact with certain medications due to effects on drug-metabolizing enzymes and the central nervous system.

May enhance effects of sedative drugs.

drug · sedative medications

CautionLimited

Neden

Apigenin can enhance GABAergic signaling, potentially increasing the sedative effects of CNS depressants such as benzodiazepines or barbiturates.

Öneri

Consult a healthcare provider before combining with sedatives; monitor for excess drowsiness.

S5 · Examine.com – Apigenin

May interact with blood thinners.

drug · anticoagulant or antiplatelet drugs

CautionLimited

Neden

Apigenin can influence cytochrome P450 enzymes involved in drug metabolism, possibly affecting levels or effects of anticoagulant medications.

Öneri

Consult with a clinician before use if taking these medications; monitor for signs of bleeding.

S7 · Drug Metabolism and Disposition – Drug interactions with flavonoids

May cause allergic reactions in sensitive individuals.

food · chamomile or related plants (Asteraceae family)

AvoidLimited

Neden

Individuals allergic to chamomile or related plants may react to apigenin-containing supplements.

Öneri

Avoid use if allergic.

S5 · Examine.com – Apigenin

Etki mekanizmaları

Nasıl çalıştığına dair kısa açıklamalar

Inhibition of inflammatory pathways

Apigenin suppresses the activation of NF-κB and other inflammatory mediators, reducing the expression of pro-inflammatory cytokines.

S2 · PubMed – Anti-inflammatory activity of apigenin S8 · International Journal of Molecular Sciences – Apigenin and inflammation

Modulation of GABA receptors

Apigenin binds to GABA(A) receptors in the brain, causing mild sedation and contributing to anxiolytic effects.

S3 · PubMed – Apigenin for anxiety: Chamomile extract clinical trial S5 · Examine.com – Apigenin

Antioxidant action

Directly scavenges reactive oxygen species and upregulates endogenous antioxidant defenses.

S1 · NIH Office of Dietary Supplements – Flavonoids Fact Sheet S6 · Molecules – Bioavailability and food sources of apigenin

Cell cycle arrest and apoptosis in cancer cells

Induces cell cycle arrest and promotes apoptosis in various cancer cell types in laboratory conditions.

S4 · Cancer Letters – Anticancer mechanisms of apigenin

Kaynaklar ve Referanslar

Bu ifadelerin dayandığı birincil kaynaklar ve incelemeler

8 sources

NIH Office of Dietary Supplements – Flavonoids Fact Sheet

PubMed – Anti-inflammatory activity of apigenin

PubMed – Apigenin for anxiety: Chamomile extract clinical trial

Cancer Letters – Anticancer mechanisms of apigenin

Examine.com – Apigenin

Molecules – Bioavailability and food sources of apigenin

Drug Metabolism and Disposition – Drug interactions with flavonoids

International Journal of Molecular Sciences – Apigenin and inflammation

Son güncelleme: 7 Mart 2026

Bu bilgiler yalnızca bilgilendirme amaçlıdır ve tıbbi tavsiye yerine geçmez.