Genistein
Genistein is a soy isoflavone (phytoestrogen) supplement, most studied for menopause symptom relief, bone health, and potential anticancer properties.
Genistein is a plant-derived isoflavone commonly found in soy products. It acts as a phytoestrogen and is used primarily for its potential benefits in menopausal symptom management, bone health, and hormone-related health conditions.
Genistein is supported by moderate quality evidence mainly from randomized trials in menopausal symptom relief and bone health, with emerging observational and preclinical evidence for anticancer effects.
Menopausal symptom relief
ModerateGenistein supplementation may reduce frequency and severity of hot flashes and improve other menopausal vasomotor symptoms.
Bone health support
ModerateDaily genistein may help maintain or improve bone mineral density in postmenopausal women, potentially lowering risk of osteoporosis when combined with calcium and vitamin D.
Potential anticancer properties
LimitedGenistein may modulate estrogen signaling and inhibit cell proliferation in certain cancers, based on observational studies and preclinical models; clinical benefits in cancer prevention or treatment are not confirmed.
Antioxidant and anti-inflammatory effects
LimitedGenistein exhibits antioxidant activity and reduces some markers of inflammation in preclinical and limited human studies.
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